A quantitative study of α-synuclein pathology in fifteen cases of dementia associated with Parkinson disease

Richard A. Armstrong*, Paul T. Kotzbauer, Joel S. Perlmutter, Meghan C. Campbell, Kyle M. Hurth, Robert E. Schmidt, Nigel J. Cairns

*Corresponding author for this work

Research output: Contribution to journalArticle

Abstract

The α-synuclein-immunoreactive pathology of dementia associated with Parkinson disease (DPD) comprises Lewy bodies (LB), Lewy neurites (LN), and Lewy grains (LG). The densities of LB, LN, LG together with vacuoles, neurons, abnormally enlarged neurons (EN), and glial cell nuclei were measured in fifteen cases of DPD. Densities of LN and LG were up to 19 and 70 times those of LB, respectively, depending on region. Densities were significantly greater in amygdala, entorhinal cortex (EC), and sectors CA2/CA3 of the hippocampus, whereas middle frontal gyrus, sector CA1, and dentate gyrus were least affected. Low densities of vacuoles and EN were recorded in most regions. There were differences in the numerical density of neurons between regions, but no statistical difference between patients and controls. In the cortex, the density of LB and vacuoles was similar in upper and lower laminae, while the densities of LN and LG were greater in upper cortex. The densities of LB, LN, and LG were positively correlated. Principal components analysis suggested that DPD cases were heterogeneous with pathology primarily affecting either hippocampus or cortex. The data suggest in DPD: (1) ratio of LN and LG to LB varies between regions, (2) low densities of vacuoles and EN are present in most brain regions, (3) degeneration occurs across cortical laminae, upper laminae being particularly affected, (4) LB, LN and LG may represent degeneration of the same neurons, and (5) disease heterogeneity may result from variation in anatomical pathway affected by cell-to-cell transfer of α-synuclein. © 2013 Springer-Verlag Wien.

Original languageEnglish
Pages (from-to)171-181
Number of pages11
JournalJournal of Neural Transmission
Volume121
Issue number2
Early online date31 Aug 2013
DOIs
Publication statusPublished - 28 Feb 2014

Fingerprint

Synucleins
Lewy Bodies
Neurites
Parkinson Disease
Dementia
Pathology
Vacuoles
Neurons
Hippocampus
Nerve Degeneration
Entorhinal Cortex
Dentate Gyrus
Principal Component Analysis
Amygdala
Cell Nucleus
Neuroglia
Brain

Keywords

  • α-Synuclein
  • Lewy bodies (LB)
  • Lewy grains (LG)
  • Lewy neurites (LN)
  • Parkinson disease with dementia (DPD)
  • principal components analysis (PCA)

Cite this

Armstrong, R. A., Kotzbauer, P. T., Perlmutter, J. S., Campbell, M. C., Hurth, K. M., Schmidt, R. E., & Cairns, N. J. (2014). A quantitative study of α-synuclein pathology in fifteen cases of dementia associated with Parkinson disease. Journal of Neural Transmission, 121(2), 171-181. https://doi.org/10.1007/s00702-013-1084-z
Armstrong, Richard A. ; Kotzbauer, Paul T. ; Perlmutter, Joel S. ; Campbell, Meghan C. ; Hurth, Kyle M. ; Schmidt, Robert E. ; Cairns, Nigel J. / A quantitative study of α-synuclein pathology in fifteen cases of dementia associated with Parkinson disease. In: Journal of Neural Transmission. 2014 ; Vol. 121, No. 2. pp. 171-181.
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Armstrong, RA, Kotzbauer, PT, Perlmutter, JS, Campbell, MC, Hurth, KM, Schmidt, RE & Cairns, NJ 2014, 'A quantitative study of α-synuclein pathology in fifteen cases of dementia associated with Parkinson disease', Journal of Neural Transmission, vol. 121, no. 2, pp. 171-181. https://doi.org/10.1007/s00702-013-1084-z

A quantitative study of α-synuclein pathology in fifteen cases of dementia associated with Parkinson disease. / Armstrong, Richard A.; Kotzbauer, Paul T.; Perlmutter, Joel S.; Campbell, Meghan C.; Hurth, Kyle M.; Schmidt, Robert E.; Cairns, Nigel J.

In: Journal of Neural Transmission, Vol. 121, No. 2, 28.02.2014, p. 171-181.

Research output: Contribution to journalArticle

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