A quantitative study of the pathological lesions in the neocortex and hippocampus of twelve patients with corticobasal degeneration

Richard A. Armstrong*, Nigel J. Cairns, Peter L. Lantos

*Corresponding author for this work

Research output: Contribution to journalArticle

Abstract

The density of ballooned neurons (BN), tau-positive neurons with inclusion bodies (tau+ neurons), and tau-positive plaques (tau+ plaques) was determined in sections of the frontal, parietal, and temporal lobe in 12 patients with corticobasal degeneration (CBD). No significant differences in the mean density of BN and tau+ neurons were observed between neocortical regions. In the hippocampus, the densities of BN were significantly lower than in the neocortex, and densities of tau+ neurons were greater in sectors CA1 and CA2, compared with CA3 and CA4. Tau+ plaques were present in one or more brain regions in six patients. Significantly more BN were recorded in the lower (laminae V/VI) compared with the upper cortex (laminae I/II/III) but tau+ neurons were equally frequent in the upper and lower cortex. No significant correlations were observed between the densities of BN and tau+ neurons, but the densities of BN in the superior temporal gyrus and tau+ plaques in the frontal cortex were positively correlated with age. A principal components analysis (PCA) suggested that differences in the density of tau+ neurons in the frontal and motor cortex were the most important sources of variation between patients. In addition, one patient with a particularly high density of tau+ neurons in the hippocampus appeared to be atypical of the patient group studied. The data support the hypothesis that, although clinically heterogeneous, CBD is a pathologically distinct disorder. (C) 2000 Academic Press.

Original languageEnglish
Pages (from-to)348-356
Number of pages9
JournalExperimental Neurology
Volume163
Issue number2
DOIs
Publication statusPublished - Jun 2000

Keywords

  • corticobasal degeneration
  • ballooned neurons
  • Tau positive neurons
  • Tau positive plaques
  • paired helical filaments
  • Pick's disease

Fingerprint Dive into the research topics of 'A quantitative study of the pathological lesions in the neocortex and hippocampus of twelve patients with corticobasal degeneration'. Together they form a unique fingerprint.

  • Cite this