TY - JOUR
T1 - Abnormal thalamocortical dynamics may be altered by deep brain stimulation
T2 - using magnetoencephalography to study phantom limb pain
AU - Ray, N.J.
AU - Jenkinson, N.
AU - Kringelbach, M.L.
AU - Hansen, P.C.
AU - Pereira, E.A.
AU - Brittain, J.S.
AU - Holland, P.
AU - Holliday, I.E.
AU - Owen, S.
AU - Stein, J.
AU - Aziz, T.
PY - 2009/1
Y1 - 2009/1
N2 - Deep brain stimulation (DBS) is used to alleviate chronic pain. Using magnetoencephalography (MEG) to study the mechanisms of DBS for pain is difficult because of the artefact caused by the stimulator. We were able to record activity over the occipital lobe of a patient using DBS for phantom limb pain during presentation of a visual stimulus. This demonstrates that MEG can be used to study patients undergoing DBS provided control stimuli are used to check the reliability of the data. We then asked the patient to rate his pain during and off DBS. Correlations were found between these ratings and power in theta (6-9) and beta bands (12-30). Further, there was a tendency for frequencies under 25 Hz to correlate with each other after a period off stimulation compared with immediately after DBS. The results are interpreted as reflecting abnormal thalamocortical dynamics, previously implicated in painful syndromes.
AB - Deep brain stimulation (DBS) is used to alleviate chronic pain. Using magnetoencephalography (MEG) to study the mechanisms of DBS for pain is difficult because of the artefact caused by the stimulator. We were able to record activity over the occipital lobe of a patient using DBS for phantom limb pain during presentation of a visual stimulus. This demonstrates that MEG can be used to study patients undergoing DBS provided control stimuli are used to check the reliability of the data. We then asked the patient to rate his pain during and off DBS. Correlations were found between these ratings and power in theta (6-9) and beta bands (12-30). Further, there was a tendency for frequencies under 25 Hz to correlate with each other after a period off stimulation compared with immediately after DBS. The results are interpreted as reflecting abnormal thalamocortical dynamics, previously implicated in painful syndromes.
KW - chronic pain
KW - magnetoencephalography
KW - phantom limb
UR - http://www.scopus.com/inward/record.url?scp=56949100519&partnerID=8YFLogxK
U2 - 10.1016/j.jocn.2008.03.004
DO - 10.1016/j.jocn.2008.03.004
M3 - Article
C2 - 19019684
AN - SCOPUS:56949100519
SN - 0967-5868
VL - 16
SP - 32
EP - 36
JO - Journal of Clinical Neuroscience
JF - Journal of Clinical Neuroscience
IS - 1
ER -