Abnormal visual habituation in pediatric photosensitive epilepsy

Daniela Brazzo, Giorgio Di Lorenzo, P. Bill, M. Fasce, G. Papalia, P. Veggiotti, Stefano Seri

Research output: Contribution to journalArticle

Abstract

Objective - To investigate visual habituation – a measure of visual cortical excitability – in photosensitive patients in pediatric age and compare the findings with a matched sample with idiopathic generalized epilepsies without photosensitivity and with normally developing children.
Methods - We presented a full-field black-and-white checkerboard pattern, at 3 reversal/s with 100% contrast binocularly for 600 consecutive trials and measured the N75–P100 and P100–N145 pattern-reversal visual evoked potential inter-peak amplitudes and N75, P100, N145 latencies for the six blocks of 100 responses. As a measure of habituation we used the slope of the linear regression line of the N75–P100 and P100–N145 peak-to-peak amplitudes. The slope of the linear regression line of the N75–P100 and P100–N145 latencies was also analyzed.
Results - Statistical analysis revealed significant differences between the three groups in the slope index of N75–P100 PR-VEP amplitude, with increased or constant amplitude in the PS group compare to the IGE and ND across the six blocks.
Conclusions - Our results support the notion that photosensitivity is associated with altered control of excitatory and inhibitory cortical processes. The causal relationship between habituation deficit and photo-paroxysmal response needs to be further investigated with longitudinal studies.

Significance
This study supports the hypothesis that suppression of PR-VEP is a sensitive intermediate phenotype, which discriminates patients with photosensitivity from those with generalized epilepsies in pediatric age.

Original languageEnglish
Pages (from-to)16-20
Number of pages5
JournalClinical Neurophysiology
Volume122
Issue number1
DOIs
Publication statusPublished - Jan 2011

Fingerprint

Reflex Epilepsy
Linear Models
Pediatrics
Generalized Epilepsy
Visual Evoked Potentials
Longitudinal Studies
Phenotype

Keywords

  • photosensitivity
  • epilepsy
  • habituation
  • sensory gating
  • pattern-reversal VEP

Cite this

Brazzo, D., Di Lorenzo, G., Bill, P., Fasce, M., Papalia, G., Veggiotti, P., & Seri, S. (2011). Abnormal visual habituation in pediatric photosensitive epilepsy. Clinical Neurophysiology , 122(1), 16-20. https://doi.org/10.1016/j.clinph.2010.06.002
Brazzo, Daniela ; Di Lorenzo, Giorgio ; Bill, P. ; Fasce, M. ; Papalia, G. ; Veggiotti, P. ; Seri, Stefano. / Abnormal visual habituation in pediatric photosensitive epilepsy. In: Clinical Neurophysiology . 2011 ; Vol. 122, No. 1. pp. 16-20.
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Brazzo, D, Di Lorenzo, G, Bill, P, Fasce, M, Papalia, G, Veggiotti, P & Seri, S 2011, 'Abnormal visual habituation in pediatric photosensitive epilepsy', Clinical Neurophysiology , vol. 122, no. 1, pp. 16-20. https://doi.org/10.1016/j.clinph.2010.06.002

Abnormal visual habituation in pediatric photosensitive epilepsy. / Brazzo, Daniela; Di Lorenzo, Giorgio; Bill, P.; Fasce, M.; Papalia, G.; Veggiotti, P.; Seri, Stefano.

In: Clinical Neurophysiology , Vol. 122, No. 1, 01.2011, p. 16-20.

Research output: Contribution to journalArticle

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AU - Brazzo, Daniela

AU - Di Lorenzo, Giorgio

AU - Bill, P.

AU - Fasce, M.

AU - Papalia, G.

AU - Veggiotti, P.

AU - Seri, Stefano

N1 - Copyright © 2010 International Federation of Clinical Neurophysiology. Published by Elsevier Ireland Ltd. All rights reserved.

PY - 2011/1

Y1 - 2011/1

N2 - Objective - To investigate visual habituation – a measure of visual cortical excitability – in photosensitive patients in pediatric age and compare the findings with a matched sample with idiopathic generalized epilepsies without photosensitivity and with normally developing children.Methods - We presented a full-field black-and-white checkerboard pattern, at 3 reversal/s with 100% contrast binocularly for 600 consecutive trials and measured the N75–P100 and P100–N145 pattern-reversal visual evoked potential inter-peak amplitudes and N75, P100, N145 latencies for the six blocks of 100 responses. As a measure of habituation we used the slope of the linear regression line of the N75–P100 and P100–N145 peak-to-peak amplitudes. The slope of the linear regression line of the N75–P100 and P100–N145 latencies was also analyzed.Results - Statistical analysis revealed significant differences between the three groups in the slope index of N75–P100 PR-VEP amplitude, with increased or constant amplitude in the PS group compare to the IGE and ND across the six blocks.Conclusions - Our results support the notion that photosensitivity is associated with altered control of excitatory and inhibitory cortical processes. The causal relationship between habituation deficit and photo-paroxysmal response needs to be further investigated with longitudinal studies.SignificanceThis study supports the hypothesis that suppression of PR-VEP is a sensitive intermediate phenotype, which discriminates patients with photosensitivity from those with generalized epilepsies in pediatric age.

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DO - 10.1016/j.clinph.2010.06.002

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SN - 1388-2457

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Brazzo D, Di Lorenzo G, Bill P, Fasce M, Papalia G, Veggiotti P et al. Abnormal visual habituation in pediatric photosensitive epilepsy. Clinical Neurophysiology . 2011 Jan;122(1):16-20. https://doi.org/10.1016/j.clinph.2010.06.002