Advanced multimodal laser imaging tool for urothelial carcinoma diagnosis (AMPLITUDE)

Sergey Kurilchik, Mauro Gacci, Riccardo Cicchi, Francesco S. Pavone, Simone Morselli, Sergio Serni, M. H. Chou, Mikko Närhi, Edik Rafailov, Neil Stewart, Cordelia Lennon, Regina Gumenyuk*

*Corresponding author for this work

Research output: Contribution to journalReview article

Abstract

Bladder cancer (BC) is the eleventh most diagnosed cancer worldwide. The age-standardized incidence rate (per 100 000 person/years) is 9.0 for men and 2.2 for women [1]. Urothelial carcinoma (UC) represents about 90% of all bladder tumors, thus carrying an enormous social and economic burden [2]. UCs are classified in different stages and grades, depending on their invasiveness and on their degree of cytological abnormalities. The key aspect for a positive prognosis is the early and accurate diagnosis of the lesion stage, in order to identify the most aggressive disease forms and treat them promptly. It is well known that tissue metabolism constitutes a basic mechanism, which is at the base of many pathologies, especially BC. Being able to detect and characterize tissue metabolism and molecular fingerprints at the cellular level could be a key aspect in characterizing the pathology and enabling both early detection and therapy monitoring. The new European Union Horizon 2020 project called AMPLITUDE, the ‘Advanced Multimodal Photonics Laser Imaging Tool for Urothelial Diagnosis in Endoscopy’, starting in January 2020, proposes the development of an advanced multi-modal imaging tool exploiting new laser technologies in an approach combining confocal and non-linear imaging to fulfil unmet clinical needs in terms of the specificity and accuracy of urothelial cancer diagnosis and therapy monitoring. The project is coordinated by Tampere University (Finland) and carried out in cooperation with leading European research organizations including Aston Insitute of Photonic Technologies—AIPT (UK), Consiglio Nazionale delle Ricerche—CNR (Italy), Institute of Photonic Sciences—ICFO (Spain), University of Milan-Bicocca, Modus Research and Innovation Ltd. (UK) and University of Florence (Italy), as well as industrial partners: Ampliconyx Oy (Finland), Femtonics Ltd. (Hungary), HC Photonics (Taiwan), and LEONI Fiber Optics GmbH (Germany).

Original languageEnglish
Article number021001
JournalJPhys Photonics
Volume2
Issue number2
DOIs
Publication statusPublished - 30 Mar 2020

Bibliographical note

Original content from this work may be used under the terms of the Creative Commons Attribution 4.0 license. Any further distribution of this work must maintain attribution to the author(s) and the title of the work, journal citation and DOI.

Funding: This project has received funding from the European Union’s Horizon 2020 research and innovation
programme under grant agreement No 871277 and is an initiative of the Photonics Public Private
Partnership.

Keywords

  • 3rd biological window
  • Bladder cancer
  • Confocal microscopy
  • Multiphoton imaging
  • Short-pulsed laser

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