Ageing effect on flicker-induced diameter changes in retinal microvessels of healthy individuals

Swathi Seshadri, Aniko Ekart, Doina Gherghel*

*Corresponding author for this work

Research output: Contribution to journalArticle

Abstract

Purpose: To compare flicker-induced retinal vessel diameter changes in varying age groups with low cardiovascular risk.

Methods: Retinal vascular reactivity to flicker light was assessed by means of dynamic retinal vessel analysis in 57 participants aged 19-30 years, 75 participants aged 31-50 years and 62 participants aged 51-70 years participants. Other assessments included carotid intima-media thickness (c-IMT), augmentation index (AIx), blood pressure profiles, blood lipid metabolism markers and Framingham risk scores (FRS).

Results: Retinal arterial dilation amplitude (DA) and postflicker percentage constriction (MC%) were significantly decreased in the oldest group compared to the middle-aged (p = 0.028; p = 0.021) and youngest group (p = 0.003; p = 0.026). The arterial constriction slope (Slope<inf>AC</inf>) was also decreased in the oldest group compared to the youngest group (p = 0.027). On the venous side, MC% was decreased in the middle-aged and oldest groups in comparison with the youngest group (p = 0.015; p = 0.010, respectively). Additionally, men exhibited increased arterial DA (p = 0.007), and percentage dilation (MD%, p < 0.001) in comparison with women, but only in the youngest age group. Both AIx and c-IMT scores increased with age (both p < 0.001); however, no correlations were found between the observed differences in the measured retinal vascular function and systemic parameters.

Conclusion: In individuals with low cardiovascular risk, there are age-related differences in flicker-induced retinal vessel diameter changes throughout the entire functional response curve for arteries and veins. Gender differences mainly affect the arterial dilatory phase and are only present in young individuals.

Original languageEnglish
Pages (from-to)e35-e42
JournalActa Ophthalmologica
Volume94
Issue number1
Early online date6 Jul 2015
DOIs
Publication statusPublished - Feb 2016

Bibliographical note

This is the peer reviewed version of the following article: Seshadri, S., Ekart, A., & Gherghel, D. (2016). Ageing effect on flicker-induced diameter changes in retinal microvessels of healthy individuals. Acta ophthalmologica, 94(1), e35-e42, which has been published in final form at http://dx.doi.org/10.1111/aos.12786. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.

Keywords

  • ageing
  • cardiovascular risk
  • dynamic retinal vessel analysis
  • retina
  • vascular function

Fingerprint Dive into the research topics of 'Ageing effect on flicker-induced diameter changes in retinal microvessels of healthy individuals'. Together they form a unique fingerprint.

  • Cite this