Amino acid-modified spray-dried powders with enhanced aerosolisation properties for pulmonary drug delivery

Peter C. Seville*, Tristan P. Learoyd, Hao-Ying Li, I.J. Williamson, James C. Birchall

*Corresponding author for this work

Research output: Contribution to journalArticle

Abstract

In this study, the amino acids arginine, aspartic acid, leucine, phenylalanine and threonine were investigated as 'dispersibility enhancers' in spray-dried powders for inhalation. Parameters such as spray-dried yield, tapped density, and Carr's Index were not predictive of aerosolisation performance. In addition, whilst the majority of amino acid-modified powders displayed suitable particle size distribution for pulmonary administration and potentially favourable low moisture content, in vitro particle deposition was only enhanced for the leucine-modified powder. In summary, leucine can be used to enhance the dispersibility and aerosolisation properties of spray-dried powders for pulmonary drug delivery. © 2007 Elsevier B.V. All rights reserved.

Original languageEnglish
Pages (from-to)40-50
Number of pages11
JournalPowder Technology
Volume178
Issue number1
DOIs
Publication statusPublished - 5 Sep 2007

Fingerprint

Drug delivery
Powders
leucine
sprayers
amino acids
Amino acids
delivery
drugs
Leucine
Amino Acids
aspartic acid
Arginine
phenylalanine
respiration
Threonine
particle size distribution
Phenylalanine
Aspartic Acid
Particle size analysis
moisture content

Keywords

  • amino acids
  • dispersibility
  • pulmonary deposition
  • salbutamol sulphate
  • spray-drying

Cite this

Seville, Peter C. ; Learoyd, Tristan P. ; Li, Hao-Ying ; Williamson, I.J. ; Birchall, James C. / Amino acid-modified spray-dried powders with enhanced aerosolisation properties for pulmonary drug delivery. In: Powder Technology. 2007 ; Vol. 178, No. 1. pp. 40-50.
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Amino acid-modified spray-dried powders with enhanced aerosolisation properties for pulmonary drug delivery. / Seville, Peter C.; Learoyd, Tristan P.; Li, Hao-Ying; Williamson, I.J.; Birchall, James C.

In: Powder Technology, Vol. 178, No. 1, 05.09.2007, p. 40-50.

Research output: Contribution to journalArticle

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T1 - Amino acid-modified spray-dried powders with enhanced aerosolisation properties for pulmonary drug delivery

AU - Seville, Peter C.

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AU - Birchall, James C.

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AB - In this study, the amino acids arginine, aspartic acid, leucine, phenylalanine and threonine were investigated as 'dispersibility enhancers' in spray-dried powders for inhalation. Parameters such as spray-dried yield, tapped density, and Carr's Index were not predictive of aerosolisation performance. In addition, whilst the majority of amino acid-modified powders displayed suitable particle size distribution for pulmonary administration and potentially favourable low moisture content, in vitro particle deposition was only enhanced for the leucine-modified powder. In summary, leucine can be used to enhance the dispersibility and aerosolisation properties of spray-dried powders for pulmonary drug delivery. © 2007 Elsevier B.V. All rights reserved.

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