Amino acid-modified spray-dried powders with enhanced aerosolisation properties for pulmonary drug delivery

Peter C. Seville*, Tristan P. Learoyd, Hao-Ying Li, I.J. Williamson, James C. Birchall

*Corresponding author for this work

Research output: Contribution to journalArticle

Abstract

In this study, the amino acids arginine, aspartic acid, leucine, phenylalanine and threonine were investigated as 'dispersibility enhancers' in spray-dried powders for inhalation. Parameters such as spray-dried yield, tapped density, and Carr's Index were not predictive of aerosolisation performance. In addition, whilst the majority of amino acid-modified powders displayed suitable particle size distribution for pulmonary administration and potentially favourable low moisture content, in vitro particle deposition was only enhanced for the leucine-modified powder. In summary, leucine can be used to enhance the dispersibility and aerosolisation properties of spray-dried powders for pulmonary drug delivery. © 2007 Elsevier B.V. All rights reserved.

Original languageEnglish
Pages (from-to)40-50
Number of pages11
JournalPowder Technology
Volume178
Issue number1
DOIs
Publication statusPublished - 5 Sep 2007

Keywords

  • amino acids
  • dispersibility
  • pulmonary deposition
  • salbutamol sulphate
  • spray-drying

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