An interdisciplinary mixed-methods approach to developing antimicrobial stewardship interventions: Protocol for the Preserving Antibiotics through Safe Stewardship (PASS) Research Programme [version 1; peer review: awaiting peer review]

Laura Shallcross, Fabiana Lorencatto, Christopher Fuller, Carolyn Tarrant, Jonathan West, Rosanna Traina, Catherine Smith, Gillian Forbes, Elise Crayton, Patrick Rockenschaub, Peter Dutey-Magni, Emma Richardson, Ellen Fragaszy, Susan Michie, Andrew Hayward, PASS Research Group

Research output: Contribution to journalArticle

Abstract

Behaviour change is key to combating antimicrobial resistance. Antimicrobial stewardship (AMS) programmes promote and monitor judicious antibiotic use, but there is little consideration of behavioural and social influences when designing interventions. We outline a programme of research which aims to co-design AMS interventions across healthcare settings, by integrating data-science, evidence- synthesis, behavioural-science and user-centred design.
The project includes three work-packages (WP):
WP1 (Identifying patterns of prescribing): analysis of electronic health-records to identify prescribing patterns in care-homes, primary-care, and secondary-care. An online survey will investigate consulting/antibiotic-seeking behaviours in members of the public.
WP2 (Barriers and enablers to prescribing in practice): Semi-structured interviews and observations of practice to identify barriers/enablers to prescribing, influences on antibiotic-seeking behaviour and the social/contextual factors underpinning prescribing. Systematic reviews of AMS interventions to identify the components of existing interventions associated with effectiveness. Design workshops to identify constraints influencing the form of the intervention. Interviews conducted with healthcare-professionals in community pharmacies, care-homes, primary-, and secondary-care and with members of the public. Topic guides and analysis based on the Theoretical Domains Framework. Observations conducted in care-homes, primary and secondary-care with analysis drawing on grounded theory. Systematic reviews of interventions in each setting will be conducted, and interventions described using the Behaviour Change Technique taxonomy v1. Design workshops in care-homes, primary-, and secondary care.
WP3 (Co-production of interventions and dissemination). Findings will be integrated to identify opportunities for interventions, and assess whether existing interventions target influences on antibiotic use. Stakeholder panels will be assembled to co-design and refine interventions in each setting, applying the Affordability, Practicability, Effectiveness, Acceptability, Side-effects and Equity (APEASE) criteria to prioritise candidate interventions.
Outputs will inform development of new AMS interventions and/or optimisation of existing interventions. We will also develop web-resources for stakeholders providing analyses of antibiotic prescribing patterns, prescribing behaviours, and evidence reviews.
Original languageEnglish
Article number8
JournalWellcome Open Research
Volume5
DOIs
Publication statusPublished - 14 Jan 2020

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Peer Review
Secondary Care
Home Care Services
Anti-Bacterial Agents
Primary Health Care
Research
Interviews
Delivery of Health Care
Behavioral Sciences
Education
Electronic Health Records
Pharmacies
Taxonomies
Health

Bibliographical note

Copyright: © 2020 Shallcross L et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Grant information: This work was supported by the Wellcome Trust through a Digital Innovator Award to FL [215742].
Funding for the project was received from the Economic and Social Research Council as part of a Antimicrobial Resistance programme grant [ES-P008321-1].

Cite this

Shallcross, Laura ; Lorencatto, Fabiana ; Fuller, Christopher ; Tarrant, Carolyn ; West, Jonathan ; Traina, Rosanna ; Smith, Catherine ; Forbes, Gillian ; Crayton, Elise ; Rockenschaub, Patrick ; Dutey-Magni, Peter ; Richardson, Emma ; Fragaszy, Ellen ; Michie, Susan ; Hayward, Andrew ; Group, PASS Research. / An interdisciplinary mixed-methods approach to developing antimicrobial stewardship interventions: Protocol for the Preserving Antibiotics through Safe Stewardship (PASS) Research Programme [version 1; peer review: awaiting peer review]. In: Wellcome Open Research. 2020 ; Vol. 5.
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abstract = "Behaviour change is key to combating antimicrobial resistance. Antimicrobial stewardship (AMS) programmes promote and monitor judicious antibiotic use, but there is little consideration of behavioural and social influences when designing interventions. We outline a programme of research which aims to co-design AMS interventions across healthcare settings, by integrating data-science, evidence- synthesis, behavioural-science and user-centred design.The project includes three work-packages (WP):WP1 (Identifying patterns of prescribing): analysis of electronic health-records to identify prescribing patterns in care-homes, primary-care, and secondary-care. An online survey will investigate consulting/antibiotic-seeking behaviours in members of the public.WP2 (Barriers and enablers to prescribing in practice): Semi-structured interviews and observations of practice to identify barriers/enablers to prescribing, influences on antibiotic-seeking behaviour and the social/contextual factors underpinning prescribing. Systematic reviews of AMS interventions to identify the components of existing interventions associated with effectiveness. Design workshops to identify constraints influencing the form of the intervention. Interviews conducted with healthcare-professionals in community pharmacies, care-homes, primary-, and secondary-care and with members of the public. Topic guides and analysis based on the Theoretical Domains Framework. Observations conducted in care-homes, primary and secondary-care with analysis drawing on grounded theory. Systematic reviews of interventions in each setting will be conducted, and interventions described using the Behaviour Change Technique taxonomy v1. Design workshops in care-homes, primary-, and secondary care.WP3 (Co-production of interventions and dissemination). Findings will be integrated to identify opportunities for interventions, and assess whether existing interventions target influences on antibiotic use. Stakeholder panels will be assembled to co-design and refine interventions in each setting, applying the Affordability, Practicability, Effectiveness, Acceptability, Side-effects and Equity (APEASE) criteria to prioritise candidate interventions. Outputs will inform development of new AMS interventions and/or optimisation of existing interventions. We will also develop web-resources for stakeholders providing analyses of antibiotic prescribing patterns, prescribing behaviours, and evidence reviews.",
author = "Laura Shallcross and Fabiana Lorencatto and Christopher Fuller and Carolyn Tarrant and Jonathan West and Rosanna Traina and Catherine Smith and Gillian Forbes and Elise Crayton and Patrick Rockenschaub and Peter Dutey-Magni and Emma Richardson and Ellen Fragaszy and Susan Michie and Andrew Hayward and Group, {PASS Research}",
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Shallcross, L, Lorencatto, F, Fuller, C, Tarrant, C, West, J, Traina, R, Smith, C, Forbes, G, Crayton, E, Rockenschaub, P, Dutey-Magni, P, Richardson, E, Fragaszy, E, Michie, S, Hayward, A & Group, PASSR 2020, 'An interdisciplinary mixed-methods approach to developing antimicrobial stewardship interventions: Protocol for the Preserving Antibiotics through Safe Stewardship (PASS) Research Programme [version 1; peer review: awaiting peer review]', Wellcome Open Research, vol. 5, 8. https://doi.org/10.12688/wellcomeopenres.15554.1

An interdisciplinary mixed-methods approach to developing antimicrobial stewardship interventions: Protocol for the Preserving Antibiotics through Safe Stewardship (PASS) Research Programme [version 1; peer review: awaiting peer review]. / Shallcross, Laura; Lorencatto, Fabiana; Fuller, Christopher; Tarrant, Carolyn; West, Jonathan; Traina, Rosanna; Smith, Catherine; Forbes, Gillian; Crayton, Elise; Rockenschaub, Patrick; Dutey-Magni, Peter; Richardson, Emma; Fragaszy, Ellen; Michie, Susan; Hayward, Andrew; Group, PASS Research.

In: Wellcome Open Research, Vol. 5, 8, 14.01.2020.

Research output: Contribution to journalArticle

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T1 - An interdisciplinary mixed-methods approach to developing antimicrobial stewardship interventions: Protocol for the Preserving Antibiotics through Safe Stewardship (PASS) Research Programme [version 1; peer review: awaiting peer review]

AU - Shallcross, Laura

AU - Lorencatto, Fabiana

AU - Fuller, Christopher

AU - Tarrant, Carolyn

AU - West, Jonathan

AU - Traina, Rosanna

AU - Smith, Catherine

AU - Forbes, Gillian

AU - Crayton, Elise

AU - Rockenschaub, Patrick

AU - Dutey-Magni, Peter

AU - Richardson, Emma

AU - Fragaszy, Ellen

AU - Michie, Susan

AU - Hayward, Andrew

AU - Group, PASS Research

N1 - Copyright: © 2020 Shallcross L et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Grant information: This work was supported by the Wellcome Trust through a Digital Innovator Award to FL [215742]. Funding for the project was received from the Economic and Social Research Council as part of a Antimicrobial Resistance programme grant [ES-P008321-1].

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N2 - Behaviour change is key to combating antimicrobial resistance. Antimicrobial stewardship (AMS) programmes promote and monitor judicious antibiotic use, but there is little consideration of behavioural and social influences when designing interventions. We outline a programme of research which aims to co-design AMS interventions across healthcare settings, by integrating data-science, evidence- synthesis, behavioural-science and user-centred design.The project includes three work-packages (WP):WP1 (Identifying patterns of prescribing): analysis of electronic health-records to identify prescribing patterns in care-homes, primary-care, and secondary-care. An online survey will investigate consulting/antibiotic-seeking behaviours in members of the public.WP2 (Barriers and enablers to prescribing in practice): Semi-structured interviews and observations of practice to identify barriers/enablers to prescribing, influences on antibiotic-seeking behaviour and the social/contextual factors underpinning prescribing. Systematic reviews of AMS interventions to identify the components of existing interventions associated with effectiveness. Design workshops to identify constraints influencing the form of the intervention. Interviews conducted with healthcare-professionals in community pharmacies, care-homes, primary-, and secondary-care and with members of the public. Topic guides and analysis based on the Theoretical Domains Framework. Observations conducted in care-homes, primary and secondary-care with analysis drawing on grounded theory. Systematic reviews of interventions in each setting will be conducted, and interventions described using the Behaviour Change Technique taxonomy v1. Design workshops in care-homes, primary-, and secondary care.WP3 (Co-production of interventions and dissemination). Findings will be integrated to identify opportunities for interventions, and assess whether existing interventions target influences on antibiotic use. Stakeholder panels will be assembled to co-design and refine interventions in each setting, applying the Affordability, Practicability, Effectiveness, Acceptability, Side-effects and Equity (APEASE) criteria to prioritise candidate interventions. Outputs will inform development of new AMS interventions and/or optimisation of existing interventions. We will also develop web-resources for stakeholders providing analyses of antibiotic prescribing patterns, prescribing behaviours, and evidence reviews.

AB - Behaviour change is key to combating antimicrobial resistance. Antimicrobial stewardship (AMS) programmes promote and monitor judicious antibiotic use, but there is little consideration of behavioural and social influences when designing interventions. We outline a programme of research which aims to co-design AMS interventions across healthcare settings, by integrating data-science, evidence- synthesis, behavioural-science and user-centred design.The project includes three work-packages (WP):WP1 (Identifying patterns of prescribing): analysis of electronic health-records to identify prescribing patterns in care-homes, primary-care, and secondary-care. An online survey will investigate consulting/antibiotic-seeking behaviours in members of the public.WP2 (Barriers and enablers to prescribing in practice): Semi-structured interviews and observations of practice to identify barriers/enablers to prescribing, influences on antibiotic-seeking behaviour and the social/contextual factors underpinning prescribing. Systematic reviews of AMS interventions to identify the components of existing interventions associated with effectiveness. Design workshops to identify constraints influencing the form of the intervention. Interviews conducted with healthcare-professionals in community pharmacies, care-homes, primary-, and secondary-care and with members of the public. Topic guides and analysis based on the Theoretical Domains Framework. Observations conducted in care-homes, primary and secondary-care with analysis drawing on grounded theory. Systematic reviews of interventions in each setting will be conducted, and interventions described using the Behaviour Change Technique taxonomy v1. Design workshops in care-homes, primary-, and secondary care.WP3 (Co-production of interventions and dissemination). Findings will be integrated to identify opportunities for interventions, and assess whether existing interventions target influences on antibiotic use. Stakeholder panels will be assembled to co-design and refine interventions in each setting, applying the Affordability, Practicability, Effectiveness, Acceptability, Side-effects and Equity (APEASE) criteria to prioritise candidate interventions. Outputs will inform development of new AMS interventions and/or optimisation of existing interventions. We will also develop web-resources for stakeholders providing analyses of antibiotic prescribing patterns, prescribing behaviours, and evidence reviews.

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