Anxiety Disorders in Williams Syndrome Contrasted with Intellectual Disability and the General Population: A Systematic Review and Meta-Analysis

Rachel Royston, Patricia Howlin, Jane Waite, Chris Oliver

Research output: Contribution to journalArticle

Abstract

Individuals with specific genetic syndromes associated with intellectual disability (ID), such as Williams syndrome (WS), are at increased risk for developing anxiety disorders. A systematic literature review identified sixteen WS papers that could generate pooled prevalence estimates of anxiety disorders for WS. A meta-analysis compared these estimates with prevalence estimates for the heterogeneous ID population and the general population. Estimated rates of anxiety disorders in WS were high. WS individuals were four times more likely to experience anxiety than individuals with ID, and the risk was also heightened compared to the general population. The results provide further evidence of an unusual profile of high anxiety in WS.
LanguageEnglish
Pages3765-3777
JournalJournal of Autism and Developmental Disorders
Volume47
Issue number12
DOIs
Publication statusPublished - 30 Sep 2016

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Williams Syndrome
Anxiety Disorders
Intellectual Disability
Meta-Analysis
Population
Anxiety

Bibliographical note

This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

Keywords

  • Williams syndrome
  • Anxiety disorders
  • Intellectual disability
  • Genetic syndromes
  • Meta-analysis
  • Systematic review

Cite this

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abstract = "Individuals with specific genetic syndromes associated with intellectual disability (ID), such as Williams syndrome (WS), are at increased risk for developing anxiety disorders. A systematic literature review identified sixteen WS papers that could generate pooled prevalence estimates of anxiety disorders for WS. A meta-analysis compared these estimates with prevalence estimates for the heterogeneous ID population and the general population. Estimated rates of anxiety disorders in WS were high. WS individuals were four times more likely to experience anxiety than individuals with ID, and the risk was also heightened compared to the general population. The results provide further evidence of an unusual profile of high anxiety in WS.",
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Anxiety Disorders in Williams Syndrome Contrasted with Intellectual Disability and the General Population: A Systematic Review and Meta-Analysis. / Royston, Rachel; Howlin, Patricia; Waite, Jane; Oliver, Chris .

In: Journal of Autism and Developmental Disorders, Vol. 47, No. 12, 30.09.2016, p. 3765-3777.

Research output: Contribution to journalArticle

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