Abstract
Methods: The task was administered to 25 HC and 25 patients with depression scores ranging from euthymic to depressed at the time of assessment. The task required participants to evaluate situations that were “enhancing” or “threatening” to self-esteem, directed at both oneself, and at other people. For instance, self-esteem enhancing scenarios involved vignettes of activities such as receiving praise during a sports game, while a threatening scenario involved, for example, receiving criticism at a party. Participants were then required to evaluate characters in the scenarios on the basis of positive (“kind”) or negative (“mean”) descriptors. Evaluations were classified from extremely negative to extremely positive. The frequencies of behavioral responses were analyzed using chi-square tests and fMRI data were analyzed using Statistical Parametric Mapping software.
Results: Patients differed significantly from HCs in their evaluation of threatening scenarios, directed at both oneself and at other people (p<0.001). Patients had a lower proportion of responses in the neutral category, and more responses in the positive and negative categories, relative to HCs. Neuroimaging results reveal differential patterns of prefrontal-cortical and limbic-subcortical activation in BDs throughout the task [p<0.05 (unc.)].
Conclusions: Findings will contribute to understanding difficulty in interpersonal functioning in patients with BD.
| Original language | English |
|---|---|
| Article number | 696 |
| Pages (from-to) | S199 |
| Number of pages | 1 |
| Journal | Biological Psychiatry |
| Volume | 75 |
| Issue number | 9S |
| DOIs | |
| Publication status | Published - 1 May 2014 |
| Event | 69th Annual Scientific Convention and Meeting of the Society-of-Biological-Psychiatry - New York, NY, United States Duration: 8 May 2014 → 10 May 2014 |
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Keywords
- bipolar
- social
- cognition
- self-esteem
- appraisal
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}
Assessment of social cognition in bipolar disorder. / Bobyn, Jaquiline A.; Fonseka, Bernice; MacQueen, Glenda; Hassel, Stefanie.
In: Biological Psychiatry, Vol. 75, No. 9S, 696, 01.05.2014, p. S199.Research output: Contribution to journal › Meeting abstract
TY - JOUR
T1 - Assessment of social cognition in bipolar disorder
AU - Bobyn, Jaquiline A.
AU - Fonseka, Bernice
AU - MacQueen, Glenda
AU - Hassel, Stefanie
PY - 2014/5/1
Y1 - 2014/5/1
N2 - Background: Impairment in social cognition may contribute to deficits in social functioning in patients with bipolar disorder (BD). In this study, a complex social cognition task was administered during a neuroimaging session. The behavioral and neural correlates of social cogniton in patients with BD were compared to healthy comparison (HC) subjects.Methods: The task was administered to 25 HC and 25 patients with depression scores ranging from euthymic to depressed at the time of assessment. The task required participants to evaluate situations that were “enhancing” or “threatening” to self-esteem, directed at both oneself, and at other people. For instance, self-esteem enhancing scenarios involved vignettes of activities such as receiving praise during a sports game, while a threatening scenario involved, for example, receiving criticism at a party. Participants were then required to evaluate characters in the scenarios on the basis of positive (“kind”) or negative (“mean”) descriptors. Evaluations were classified from extremely negative to extremely positive. The frequencies of behavioral responses were analyzed using chi-square tests and fMRI data were analyzed using Statistical Parametric Mapping software.Results: Patients differed significantly from HCs in their evaluation of threatening scenarios, directed at both oneself and at other people (p<0.001). Patients had a lower proportion of responses in the neutral category, and more responses in the positive and negative categories, relative to HCs. Neuroimaging results reveal differential patterns of prefrontal-cortical and limbic-subcortical activation in BDs throughout the task [p<0.05 (unc.)].Conclusions: Findings will contribute to understanding difficulty in interpersonal functioning in patients with BD.
AB - Background: Impairment in social cognition may contribute to deficits in social functioning in patients with bipolar disorder (BD). In this study, a complex social cognition task was administered during a neuroimaging session. The behavioral and neural correlates of social cogniton in patients with BD were compared to healthy comparison (HC) subjects.Methods: The task was administered to 25 HC and 25 patients with depression scores ranging from euthymic to depressed at the time of assessment. The task required participants to evaluate situations that were “enhancing” or “threatening” to self-esteem, directed at both oneself, and at other people. For instance, self-esteem enhancing scenarios involved vignettes of activities such as receiving praise during a sports game, while a threatening scenario involved, for example, receiving criticism at a party. Participants were then required to evaluate characters in the scenarios on the basis of positive (“kind”) or negative (“mean”) descriptors. Evaluations were classified from extremely negative to extremely positive. The frequencies of behavioral responses were analyzed using chi-square tests and fMRI data were analyzed using Statistical Parametric Mapping software.Results: Patients differed significantly from HCs in their evaluation of threatening scenarios, directed at both oneself and at other people (p<0.001). Patients had a lower proportion of responses in the neutral category, and more responses in the positive and negative categories, relative to HCs. Neuroimaging results reveal differential patterns of prefrontal-cortical and limbic-subcortical activation in BDs throughout the task [p<0.05 (unc.)].Conclusions: Findings will contribute to understanding difficulty in interpersonal functioning in patients with BD.
KW - bipolar
KW - social
KW - cognition
KW - self-esteem
KW - appraisal
U2 - 10.1016/j.biopsych.2014.03.015
DO - 10.1016/j.biopsych.2014.03.015
M3 - Meeting abstract
VL - 75
SP - S199
JO - Biological Psychiatry
JF - Biological Psychiatry
SN - 0006-3223
IS - 9S
M1 - 696
ER -