Asymmetry of language activation relates to regional callosal morphology following early cerebral injury

Amanda Wood, M M Saling, G D Jackson, D C Reutens

Research output: Contribution to journalArticle

Abstract

The anatomical factors underlying reorganization of language representation are yet to be elucidated, although correlations between asymmetric structures and language lateralization have been identified. Previous research has implicated the corpus callosum in the development of language lateralization. This study examined the relationship between callosal morphology and language asymmetry, using letter fluency functional magnetic resonance imaging, in 13 patients with focal epilepsy and 8 healthy controls. Regional callosal thickness was determined without relying on a priori delineation of callosal segments. We predicted that language asymmetry measured by fMRI activation laterality scores would be correlated with regional callosal thickness in both groups. However, only the degree of language activation asymmetry was significantly correlated with callosal thickness in the isthmus and the midbody of patients, and there was a significant interaction between the groups with respect to callosal thickness and language activation asymmetry. These data suggest that callosal pathways may be important for language reorganization in the context of early cerebral injury.
Original languageEnglish
Pages (from-to)427-433
Number of pages7
JournalEpilepsy and Behavior
Volume12
Issue number3
DOIs
Publication statusPublished - 1 Apr 2008

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Corpus Callosum
Language
Wounds and Injuries
Magnetic Resonance Imaging
Language Development
Partial Epilepsy
Research

Keywords

  • Adult, Brain Injuries, Brain Mapping, Cerebral Cortex, Corpus Callosum, Female, Functional Laterality, Humans, Image Processing, Computer-Assisted, Language Tests, Magnetic Resonance Imaging, Male, Neuropsychological Tests, Oxygen, Verbal Behavior

Cite this

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abstract = "The anatomical factors underlying reorganization of language representation are yet to be elucidated, although correlations between asymmetric structures and language lateralization have been identified. Previous research has implicated the corpus callosum in the development of language lateralization. This study examined the relationship between callosal morphology and language asymmetry, using letter fluency functional magnetic resonance imaging, in 13 patients with focal epilepsy and 8 healthy controls. Regional callosal thickness was determined without relying on a priori delineation of callosal segments. We predicted that language asymmetry measured by fMRI activation laterality scores would be correlated with regional callosal thickness in both groups. However, only the degree of language activation asymmetry was significantly correlated with callosal thickness in the isthmus and the midbody of patients, and there was a significant interaction between the groups with respect to callosal thickness and language activation asymmetry. These data suggest that callosal pathways may be important for language reorganization in the context of early cerebral injury.",
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Asymmetry of language activation relates to regional callosal morphology following early cerebral injury. / Wood, Amanda; Saling, M M; Jackson, G D; Reutens, D C.

In: Epilepsy and Behavior, Vol. 12, No. 3, 01.04.2008, p. 427-433.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Asymmetry of language activation relates to regional callosal morphology following early cerebral injury

AU - Wood, Amanda

AU - Saling, M M

AU - Jackson, G D

AU - Reutens, D C

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AB - The anatomical factors underlying reorganization of language representation are yet to be elucidated, although correlations between asymmetric structures and language lateralization have been identified. Previous research has implicated the corpus callosum in the development of language lateralization. This study examined the relationship between callosal morphology and language asymmetry, using letter fluency functional magnetic resonance imaging, in 13 patients with focal epilepsy and 8 healthy controls. Regional callosal thickness was determined without relying on a priori delineation of callosal segments. We predicted that language asymmetry measured by fMRI activation laterality scores would be correlated with regional callosal thickness in both groups. However, only the degree of language activation asymmetry was significantly correlated with callosal thickness in the isthmus and the midbody of patients, and there was a significant interaction between the groups with respect to callosal thickness and language activation asymmetry. These data suggest that callosal pathways may be important for language reorganization in the context of early cerebral injury.

KW - Adult, Brain Injuries, Brain Mapping, Cerebral Cortex, Corpus Callosum, Female, Functional Laterality, Humans, Image Processing, Computer-Assisted, Language Tests, Magnetic Resonance Imaging, Male, Neuropsychological Tests, Oxygen, Verbal Behavior

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