TY - JOUR
T1 - AuNPs with Cynara scolymus leaf extracts rescue arsenic-induced neurobehavioral deficits and hippocampal tissue toxicity in Balb/c mice through D1R and D2R activation
AU - Cicek, Betul
AU - Hacimuftuoglu, Ahmet
AU - Yeni, Yesim
AU - Kuzucu, Mehmet
AU - Genc, Sidika
AU - Cetin, Ahmet
AU - Yavuz, Emre
AU - Danısman, Betul
AU - Levent, Akin
AU - Ozdokur, Kemal Volkan
AU - Kantarcı, Mecit
AU - Docea, Anca Oana
AU - Siokas, Vasileios
AU - Tsarouhas, Konstantinos
AU - Coleman, Michael D
AU - Tsatsakis, Aristidis
AU - Taghizadehghalehjoughi, Ali
N1 - Copyright © 2024, Elsevier B.V. This accepted manuscript version is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International https://creativecommons.org/licenses/by-nc-nd/4.0/
PY - 2024/4
Y1 - 2024/4
N2 - The present study was designed to evaluate whether AuNPs (gold nanoparticles) synthesized with the Cynara scolymus (CS) leaf exert protective and/or alleviative effects on arsenic (As)-induced hippocampal neurotoxicity in mice. Neurotoxicity in mice was developed by orally treating 10 mg/kg/day sodium arsenite (NaAsO ) for 21 days. 10 µg/g AuNPs, 1.6 g/kg CS, and 10 µg/g CS-AuNPs were administered orally simultaneously with 10 mg/kg As. CS and CS-AuNPs treatments showed down-regulation of TNF-α and IL-1β levels. CS and CS-AuNPs also ameliorated apoptosis and reduced the alterations in the expression levels of D1 and D2 dopamine receptors induced by As. Simultaneous treatment with CS and CS-AuNPs improved As-induced learning, memory deficits, and motor coordination in mice assessed by water maze and locomotor tests, respectively. The results of this study provide evidence that CS-AuNPs demonstrated neuroprotective roles with antioxidant, anti-inflammatory, and anti-apoptotic effects, as well as improving D1 and D2 signaling, and eventually reversed neurobehavioral impairments. [Abstract copyright: Copyright © 2024 Elsevier B.V. All rights reserved.]
AB - The present study was designed to evaluate whether AuNPs (gold nanoparticles) synthesized with the Cynara scolymus (CS) leaf exert protective and/or alleviative effects on arsenic (As)-induced hippocampal neurotoxicity in mice. Neurotoxicity in mice was developed by orally treating 10 mg/kg/day sodium arsenite (NaAsO ) for 21 days. 10 µg/g AuNPs, 1.6 g/kg CS, and 10 µg/g CS-AuNPs were administered orally simultaneously with 10 mg/kg As. CS and CS-AuNPs treatments showed down-regulation of TNF-α and IL-1β levels. CS and CS-AuNPs also ameliorated apoptosis and reduced the alterations in the expression levels of D1 and D2 dopamine receptors induced by As. Simultaneous treatment with CS and CS-AuNPs improved As-induced learning, memory deficits, and motor coordination in mice assessed by water maze and locomotor tests, respectively. The results of this study provide evidence that CS-AuNPs demonstrated neuroprotective roles with antioxidant, anti-inflammatory, and anti-apoptotic effects, as well as improving D1 and D2 signaling, and eventually reversed neurobehavioral impairments. [Abstract copyright: Copyright © 2024 Elsevier B.V. All rights reserved.]
KW - D2R
KW - D1R
KW - Arsenic
KW - Cynara scolymus
KW - AuNPs
KW - Neurotoxicity
UR - https://www.sciencedirect.com/science/article/abs/pii/S1382668924000577?via%3Dihub
UR - http://www.scopus.com/inward/record.url?scp=85189019729&partnerID=8YFLogxK
U2 - 10.1016/j.etap.2024.104417
DO - 10.1016/j.etap.2024.104417
M3 - Article
C2 - 38493879
SN - 1382-6689
VL - 107
JO - Environmental Toxicology and Pharmacology
JF - Environmental Toxicology and Pharmacology
M1 - 104417
ER -