TY - JOUR
T1 - Autonomic dysfunction is associated with brief episodes of atrial fibrillation in type 2 diabetes
AU - Rizzo, Maria Rosaria
AU - Sasso, Ferdinando Carlo
AU - Marfella, Raffaele
AU - Siniscalchi, Mario
AU - Paolisso, Pasquale
AU - Carbonara, Ornella
AU - Capoluongo, Maria Carmela
AU - Lascar, Nadia
AU - Pace, Caterina
AU - Sardu, Celestino
AU - Passavanti, Beatrice
AU - Barbieri, Michelangela
AU - Mauro, Ciro
AU - Paolisso, Giuseppe
N1 - .
PY - 2015/1/1
Y1 - 2015/1/1
N2 - Methods and Results In a multicentric cross-sectional controlled study, 1992 patients with type 2 diabetes were screened. All underwent ambulatory ECG recording for 48-hour at 3, 6, 9, and 12 months. Heart rate variability (HRV) was used as indicator of autonomic activity. One hundred seventy-six diabetics with silent atrial fibrillation episodes (SAFE group) and 288 without silent atrial fibrillation (non-SAFE group) were enrolled. These selected diabetics were matched on clinical and anthropometric data to 120 control subjects without diabetes of the control group. HRV analysis evidenced that LF/HF ratio was significantly higher in the SAFE group than in the non-SAFE group (P < 0.05) in the whole period of HM analysis. AF absolute burdens were positively correlated with LF/HF ratio (r = 0.31, P < 0.001). Multiple regression analysis showed that LF/HF ratio was an independent determinant of AF episodes.Conclusions This study originally showed a strong relationship between autonomic dysfunction and silent atrial fibrillation in type 2 diabetes.Background and Aims This study aimed to investigate the relationship between asymptomatic episodes of atrial fibrillation (AF) and abnormalities of the autonomic nervous system in type 2 diabetic patients who did not have evidence of atrial fibrillation at baseline.
AB - Methods and Results In a multicentric cross-sectional controlled study, 1992 patients with type 2 diabetes were screened. All underwent ambulatory ECG recording for 48-hour at 3, 6, 9, and 12 months. Heart rate variability (HRV) was used as indicator of autonomic activity. One hundred seventy-six diabetics with silent atrial fibrillation episodes (SAFE group) and 288 without silent atrial fibrillation (non-SAFE group) were enrolled. These selected diabetics were matched on clinical and anthropometric data to 120 control subjects without diabetes of the control group. HRV analysis evidenced that LF/HF ratio was significantly higher in the SAFE group than in the non-SAFE group (P < 0.05) in the whole period of HM analysis. AF absolute burdens were positively correlated with LF/HF ratio (r = 0.31, P < 0.001). Multiple regression analysis showed that LF/HF ratio was an independent determinant of AF episodes.Conclusions This study originally showed a strong relationship between autonomic dysfunction and silent atrial fibrillation in type 2 diabetes.Background and Aims This study aimed to investigate the relationship between asymptomatic episodes of atrial fibrillation (AF) and abnormalities of the autonomic nervous system in type 2 diabetic patients who did not have evidence of atrial fibrillation at baseline.
KW - Atrial fibrillation
KW - Autonomic nervous system
KW - ECG Holter
KW - Heart rate variability
KW - Type 2 diabetes
UR - http://www.scopus.com/inward/record.url?scp=84920516491&partnerID=8YFLogxK
UR - https://www.sciencedirect.com/science/article/pii/S1056872714002591?via%3Dihub
U2 - 10.1016/j.jdiacomp.2014.09.002
DO - 10.1016/j.jdiacomp.2014.09.002
M3 - Article
C2 - 25266244
AN - SCOPUS:84920516491
SN - 1056-8727
VL - 29
SP - 88
EP - 92
JO - Journal of Diabetes and its Complications
JF - Journal of Diabetes and its Complications
IS - 1
ER -