Bacterial bioinformatics: Pathogenesis and the genome

Kelly Paine, Darren R. Flower

Research output: Contribution to journalArticle

Abstract

As the number of completed microbial genome sequences continues to grow, there is a pressing need for the exploitation of this wealth of data through a synergistic interaction between the well established science of bacteriology andthe emergent discipline of bioinformatics. Antibiotic resistance and
pathogenicity in virulent bacteria has become an increasing problem, with even the strongest drugs useless against some species, such as multi-drug
resistant Enterococcus faecium and Mycobacteriumtuberculosis.The global spread of Human Immuno- deficiency Virus (HIV) and Acquired Immune Deficiency Syndrome (AIDS) has contributed to there emergence of tuberculosis and the threat from new and emergent diseases. To address these problems,
bacterial pathogenicity requires redefinition as Koch’s postulates become obsolete. This review discusses how the use of bacterial genomic information, and the in silico tools available at present, may aid in determining the definition of a current pathogen. The combination of both fields should provide a rapid and efficient way of assisting in the future development of antimicrobial therapies.
Original languageEnglish
Pages (from-to)357-365
Number of pages9
JournalJournal of Molecular Microbiology and Biotechnology
Volume4
Issue number4
Publication statusPublished - Jul 2002

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