Barrel Cortex as a Model System for Understanding the Molecular, Structural, and Functional Basis of Cortical Plasticity

Kevin Fox*, Stuart Greenhill, Annelies de Haan

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

In this chapter we cover the methodology for molecular, synaptic, cellular, and systems level studies of plasticity in the barrel cortex. The text is organized into four main sections. Section 1 covers methods of inducing plasticity in the barrel cortex as well as how to stimulate the whiskers in a standard way. Section 2 covers extracellular recording for systems level measures of plasticity; section 3 describes the methodology of intracellular recording in vivo for cellular level measures of plasticity, and finally, section 4 covers imaging methods used in understanding the structural plasticity of the synapse and its relationship to functional plasticity.

Original languageEnglish
Title of host publicationHandbook of Behavioral Neuroscience
PublisherElsevier
Chapter10
Pages189-212
Number of pages24
Volume28
DOIs
Publication statusPublished - 29 Aug 2019

Publication series

NameHandbook of Behavioral Neuroscience
Volume28
ISSN (Print)1569-7339

Keywords

  • Cortical circuit
  • LTD
  • LTP
  • Spine dynamics
  • Synaptic plasticity
  • Synaptic scaling

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    Fox, K., Greenhill, S., & de Haan, A. (2019). Barrel Cortex as a Model System for Understanding the Molecular, Structural, and Functional Basis of Cortical Plasticity. In Handbook of Behavioral Neuroscience (Vol. 28, pp. 189-212). (Handbook of Behavioral Neuroscience; Vol. 28). Elsevier. https://doi.org/10.1016/B978-0-12-812028-6.00010-0