Beta-amyloid deposition in the medial temporal lobe in elderly non-demented brains and in Alzheimer's disease

Richard A. Armstrong

Research output: Contribution to journalArticle

Abstract

The density of diffuse, primitive, classic and compact β-amyloid (β/A4) deposits was estimated in the medial temporal lobe in elderly non-demented brains and in Alzheimer's disease (AD). In the non-demented cases, β/A4 deposits were absent in the hippocampus but in 8/14 cases they were present in the adjacent cortical regions. Variation in β/A4 deposition in the non-demented cases was large and overlapped with that of the AD cases. The ratio of mature to diffuse β/A4 deposits was greater in the non-demented than in the AD cases. In both the non-demented cases and AD, the β/A4 deposits were clustered with, in many tissues, a regular distribution of clusters along the cortex parallel to the pia. However, the mean cluster size of the deposits in the cortex was greater in AD than in the non-demented cases. These results suggest that the spread of β/A4 pathology between the modular units of the cortex and into the hippocampus could be important factors in the development of AD.

Original languageEnglish
Pages (from-to)121-125
Number of pages5
JournalDementia and Geriatric Cognitive Disorders
Volume6
Issue number3
DOIs
Publication statusPublished - 1995

Fingerprint

Temporal Lobe
Amyloid
Alzheimer Disease
Brain
Hippocampus
Amyloid Plaques
Pathology

Keywords

  • β/A4 deposition
  • Alzheimer's disease
  • hippocampus
  • medial temporal lobe
  • non-demented brains

Cite this

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Beta-amyloid deposition in the medial temporal lobe in elderly non-demented brains and in Alzheimer's disease. / Armstrong, Richard A.

In: Dementia and Geriatric Cognitive Disorders, Vol. 6, No. 3, 1995, p. 121-125.

Research output: Contribution to journalArticle

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