Biofunctionalized carbon nanotubes in neural regeneration: a mini-review

Ji-Young Hwang, Ueon Sang Shin, Won-Cheoul Jang, Jung Keun Hyun, Ivan B Wall, Hae-Won Kim

Research output: Contribution to journalReview article

Abstract

Carbon nanotubes (CNTs) have become an intriguing and promising biomaterial platform for the regeneration and functional recovery of damaged nerve tissues. The unique electrical, structural and mechanical properties, diversity of available surface chemistry and cell-penetrating ability of CNTs have made them useful implantable matrices or carriers for the delivery of therapeutic molecules. Although there are still challenges being faced in the clinical applications of CNTs mainly due to their toxicity, many studies to overcome this issue have been published. Modification of CNTs with chemical groups to ensure their dissolution in aqueous media is one possible solution. Functionalization of CNTs with biologically relevant and effective molecules (biofunctionalization) is also a promising strategy to provide better biocompatibility and selectivity for neural regeneration. Here, we review recent advances in the use of CNTs to promote neural regeneration.

Original languageEnglish
Pages (from-to)487-97
Number of pages11
JournalNanoscale
Volume5
Issue number2
DOIs
Publication statusPublished - 21 Jan 2013

Keywords

  • Animals
  • Biocompatible Materials/chemistry
  • Drug Delivery Systems
  • Humans
  • Nanotechnology/methods
  • Nanotubes, Carbon/chemistry
  • Nerve Regeneration
  • Neurites/metabolism
  • Neurons/pathology
  • Spinal Cord Injuries/therapy
  • Stress, Mechanical

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