Biological and clinical insights from genetics of insomnia symptoms

Research output: Contribution to journalLetter

Abstract

Insomnia is a common disorder linked with adverse long-term medical and psychiatric outcomes. The underlying pathophysiological processes and causal relationships of insomnia with disease are poorly understood. Here we identified 57 loci for self-reported insomnia symptoms in the UK Biobank (n = 453,379) and confirmed their effects on self-reported insomnia symptoms in the HUNT Study (n = 14,923 cases and 47,610 controls), physician-diagnosed insomnia in the Partners Biobank (n = 2,217 cases and 14,240 controls), and accelerometer-derived measures of sleep efficiency and sleep duration in the UK Biobank (n = 83,726). Our results suggest enrichment of genes involved in ubiquitin-mediated proteolysis and of genes expressed in multiple brain regions, skeletal muscle, and adrenal glands. Evidence of shared genetic factors was found between frequent insomnia symptoms and restless legs syndrome, aging, and cardiometabolic, behavioral, psychiatric, and reproductive traits. Evidence was found for a possible causal link between insomnia symptoms and coronary artery disease, depressive symptoms, and subjective well-being.

Original languageEnglish
Pages (from-to)387–393
Number of pages7
JournalNature Genetics
Volume51
Issue number3
DOIs
Publication statusPublished - 25 Feb 2019

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Sleep Initiation and Maintenance Disorders
Psychiatry
Sleep
Restless Legs Syndrome
Adrenal Glands
Ubiquitin
Proteolysis
Genes
Coronary Artery Disease
Skeletal Muscle
Depression
Physicians
Brain

Cite this

/ Biological and clinical insights from genetics of insomnia symptoms. In: Nature Genetics. 2019 ; Vol. 51, No. 3. pp. 387–393.
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abstract = "Insomnia is a common disorder linked with adverse long-term medical and psychiatric outcomes. The underlying pathophysiological processes and causal relationships of insomnia with disease are poorly understood. Here we identified 57 loci for self-reported insomnia symptoms in the UK Biobank (n = 453,379) and confirmed their effects on self-reported insomnia symptoms in the HUNT Study (n = 14,923 cases and 47,610 controls), physician-diagnosed insomnia in the Partners Biobank (n = 2,217 cases and 14,240 controls), and accelerometer-derived measures of sleep efficiency and sleep duration in the UK Biobank (n = 83,726). Our results suggest enrichment of genes involved in ubiquitin-mediated proteolysis and of genes expressed in multiple brain regions, skeletal muscle, and adrenal glands. Evidence of shared genetic factors was found between frequent insomnia symptoms and restless legs syndrome, aging, and cardiometabolic, behavioral, psychiatric, and reproductive traits. Evidence was found for a possible causal link between insomnia symptoms and coronary artery disease, depressive symptoms, and subjective well-being.",
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Biological and clinical insights from genetics of insomnia symptoms. /.

In: Nature Genetics, Vol. 51, No. 3, 25.02.2019, p. 387–393.

Research output: Contribution to journalLetter

TY - JOUR

T1 - Biological and clinical insights from genetics of insomnia symptoms

AU - Lane, Jacqueline M.

AU - Jones, Samuel E.

AU - Dashti, Hassan S.

AU - Wood, Andrew R.

AU - Aragam, Krishna G.

AU - van Hees, Vincent T.

AU - Strand, Linn B.

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AU - Song, Yanwei

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AU - Loudon, Andrew S.

AU - Purcell, Shaun

AU - Richmond, Rebecca C.

AU - Scheer, Frank A.J.L.

AU - Schormair, Barbara

AU - Tyrrell, Jessica

AU - Winkelman, John W.

AU - Winkelmann, Juliane

AU - Martinsen, Amy E.

AU - Skogholt, Anne H.

AU - Brumpton, Ben

AU - Winsvold, Bendik S.

AU - Sivertsen, Børge

AU - Willer, Cristen J.

AU - Bragantini, Daniela

AU - Kallestad, Håvard

AU - Janszky, Imre

AU - Guzey, Ismail C.

AU - Zwart, John Anker

AU - Nielsen, Jonas B.

AU - Nilsen, Kristian B.

AU - Hveem, Kristian

AU - Fritsche, Lars

AU - Pedersen, Linda M.

AU - Strand, Linn B.

AU - Gabrielsen, Maiken E.

AU - Johnsen, Marianne B.

AU - Lie, Marie U.

AU - Engstrøm, Morten

AU - Sand, Trond

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N2 - Insomnia is a common disorder linked with adverse long-term medical and psychiatric outcomes. The underlying pathophysiological processes and causal relationships of insomnia with disease are poorly understood. Here we identified 57 loci for self-reported insomnia symptoms in the UK Biobank (n = 453,379) and confirmed their effects on self-reported insomnia symptoms in the HUNT Study (n = 14,923 cases and 47,610 controls), physician-diagnosed insomnia in the Partners Biobank (n = 2,217 cases and 14,240 controls), and accelerometer-derived measures of sleep efficiency and sleep duration in the UK Biobank (n = 83,726). Our results suggest enrichment of genes involved in ubiquitin-mediated proteolysis and of genes expressed in multiple brain regions, skeletal muscle, and adrenal glands. Evidence of shared genetic factors was found between frequent insomnia symptoms and restless legs syndrome, aging, and cardiometabolic, behavioral, psychiatric, and reproductive traits. Evidence was found for a possible causal link between insomnia symptoms and coronary artery disease, depressive symptoms, and subjective well-being.

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