Chemical synthesis of oligonucleotides containing (M+4) guanine

Ruoling Guo, Qinguo Zheng

Research output: Contribution to journalArticlepeer-review


HPLC MS/MS has shown great potential in the measurement of DNA oxidative damage. Its accuracy depends on the use of multiply isotopically labelled internal standards. In this report, multiply isotopically labelled (M + 4) guanine internal standards were prepared in the form of base, nucleoside, as well as DNA oligomer. To our knowledge, this is the first chemical synthesis of oligomers containing (M + 4) guanine, and we believe that they can be used to develop a procedure that can make further improvement to the existing analytical procedures. Copyright © Taylor & Francis, Inc.

Original languageEnglish
Pages (from-to)1081-1083
Number of pages3
JournalNucleosides, Nucleotides and Nucleic Acids
Issue number5-7
Publication statusPublished - 2005

Bibliographical note

16th International Roundtable of the International Society for Nucleosides Nucleotides and Nucleic Acids (IS3NA), Minneapolis, MN (US), 12-16 September 2004


  • DNA oxidative damage
  • internal standard
  • isotopically labelled guanine
  • oligonucleotide


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