Abstract
HPLC MS/MS has shown great potential in the measurement of DNA oxidative damage. Its accuracy depends on the use of multiply isotopically labelled internal standards. In this report, multiply isotopically labelled (M + 4) guanine internal standards were prepared in the form of base, nucleoside, as well as DNA oligomer. To our knowledge, this is the first chemical synthesis of oligomers containing (M + 4) guanine, and we believe that they can be used to develop a procedure that can make further improvement to the existing analytical procedures. Copyright © Taylor & Francis, Inc.
Original language | English |
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Pages (from-to) | 1081-1083 |
Number of pages | 3 |
Journal | Nucleosides, Nucleotides and Nucleic Acids |
Volume | 24 |
Issue number | 5-7 |
DOIs | |
Publication status | Published - 2005 |
Bibliographical note
16th International Roundtable of the International Society for Nucleosides Nucleotides and Nucleic Acids (IS3NA), Minneapolis, MN (US), 12-16 September 2004Keywords
- DNA oxidative damage
- internal standard
- isotopically labelled guanine
- oligonucleotide