C. Day, C. Bailey

Research output: Chapter in Book/Published conference outputEntry for encyclopedia/dictionary


Ciglitazone was the first antidiabetic thiazolidinedione to be described in detail (Sohda et al., 1982). The thiazolidinediones (TZDs), also termed “glitazones”, activate the nuclear peroxisome proliferator-activated receptor-gamma (PPAR-gamma). Thiazolidinediones currently in clinical use for the treatment of type 2 diabetes are rosiglitazone (withdrawn in Europe in 2010) and pioglitazone. Another TZD, troglitazone, was withdrawn due to hepatotoxicity. Ciglitazone was not introduced into clinical use.
Original languageEnglish
Title of host publicationReference module in biomedical sciences
ISBN (Print)978-0-12-801238-3
Publication statusPublished - 2016


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