Closest horizons of Hsp70 engagement to manage neurodegeneration

Artem A. Venediktov, Olga Yu Bushueva, Varvara A. Kudryavtseva, Egor A. Kuzmin, Aleksandra V. Moiseeva, Anna Baldycheva*, Igor Meglinski*, Gennadii A. Piavchenko*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review


Our review seeks to elucidate the current state-of-the-art in studies of 70-kilodalton-weighed heat shock proteins (Hsp70) in neurodegenerative diseases (NDs). The family has already been shown to play a crucial role in pathological aggregation for a wide spectrum of brain pathologies. However, a slender boundary between a big body of fundamental data and its implementation has only recently been crossed. Currently, we are witnessing an anticipated advancement in the domain with dozens of studies published every month. In this review, we briefly summarize scattered results regarding the role of Hsp70 in the most common NDs including Alzheimer’s disease (AD), Parkinson’s disease (PD), and amyotrophic lateral sclerosis (ALS). We also bridge translational studies and clinical trials to portray the output for medical practice. Available options to regulate Hsp70 activity in NDs are outlined, too.
Original languageEnglish
Article number1230436
JournalFrontiers in Molecular Neuroscience
Publication statusPublished - 19 Sept 2023

Bibliographical note

© 2023 Venediktov, Bushueva, Kudryavtseva, Kuzmin, Moiseeva, Baldycheva, Meglinski and Piavchenko. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

Funding: This study was supported by the Russian Science Foundation (project no. 23–25-00448,


  • Hsp70
  • amyotrophic lateral sclerosis
  • neurodegenerative diseases
  • neuropharmacology
  • Alzheimer’s disease


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