Controlled synthesis and processing of a poly(L-lactide-co-ε-caprolactone) copolymer for biomedical use as an absorbable monofilament surgical suture

Sujitra Ruengdechawiwat, Runglawan Somsunan, Robert Molloy, Jintana Siripitayananon, Valerie J. Franklin, Paul D. Topham, Brian J. Tighe

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Poly(L-lactide-co-ε-caprolactone) 75:25% mol, P(LL-co-CL), was synthesized via bulk ring-opening polymerisation (ROP) using a novel tin(II)alkoxide initiator, [Sn(Oct)]2DEG, at 130oC for 48 hrs. The effectiveness of this initiator was compared withthe well-known conventional tin(II) octoateinitiator, Sn(Oct)2. The P(LL-co-CL) copolymersobtained were characterized using a combination of analytical technique including: nuclear magnetic resonance spectroscopy (NMR), differential scanning calorimetry (DSC), thermogravimetry (TG) and gel permeation chromatography (GPC). The P(LL-co-CL) was melt-spun into monofilament fibres of uniform diameter and smooth surface appearance. Modification of the matrix morphology was then built into the as-spun fibresvia a series of controlled off-line annealing and hot-drawing steps.

Original languageEnglish
Title of host publicationAdvanced Materials Research IV
EditorsZhihua Guo, Jie Xu
PublisherScientific.net
Pages172-176
Number of pages5
ISBN (Print)978-3-03835-032-3
DOIs
Publication statusPublished - 19 Mar 2014
Event4th International Conference on Advanced Materials Research - Macau, China
Duration: 22 Jan 201423 Jan 2014

Publication series

NameAdvanced materials research
PublisherScientific.net
Volume894
ISSN (Print)1022-6680

Conference

Conference4th International Conference on Advanced Materials Research
Abbreviated titleICAMR 2014
CountryChina
CityMacau
Period22/01/1423/01/14

Keywords

  • ε-caprolactone
  • Absorbablesurgical suture
  • biomedical applications
  • L-lactide
  • melt spinning
  • ring-opening polymerisation
  • absorbable surgical suture

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    Ruengdechawiwat, S., Somsunan, R., Molloy, R., Siripitayananon, J., Franklin, V. J., Topham, P. D., & Tighe, B. J. (2014). Controlled synthesis and processing of a poly(L-lactide-co-ε-caprolactone) copolymer for biomedical use as an absorbable monofilament surgical suture. In Z. Guo, & J. Xu (Eds.), Advanced Materials Research IV (pp. 172-176). (Advanced materials research; Vol. 894). Scientific.net. https://doi.org/10.4028/www.scientific.net/AMR.894.172