TY - GEN
T1 - Controlled synthesis and processing of a poly(L-lactide-co-ε-caprolactone) copolymer for biomedical use as an absorbable monofilament surgical suture
AU - Ruengdechawiwat, Sujitra
AU - Somsunan, Runglawan
AU - Molloy, Robert
AU - Siripitayananon, Jintana
AU - Franklin, Valerie J.
AU - Topham, Paul D.
AU - Tighe, Brian J.
PY - 2014/3/19
Y1 - 2014/3/19
N2 - Poly(L-lactide-co-ε-caprolactone) 75:25% mol, P(LL-co-CL), was synthesized via bulk ring-opening polymerisation (ROP) using a novel tin(II)alkoxide initiator, [Sn(Oct)]2DEG, at 130oC for 48 hrs. The effectiveness of this initiator was compared withthe well-known conventional tin(II) octoateinitiator, Sn(Oct)2. The P(LL-co-CL) copolymersobtained were characterized using a combination of analytical technique including: nuclear magnetic resonance spectroscopy (NMR), differential scanning calorimetry (DSC), thermogravimetry (TG) and gel permeation chromatography (GPC). The P(LL-co-CL) was melt-spun into monofilament fibres of uniform diameter and smooth surface appearance. Modification of the matrix morphology was then built into the as-spun fibresvia a series of controlled off-line annealing and hot-drawing steps.
AB - Poly(L-lactide-co-ε-caprolactone) 75:25% mol, P(LL-co-CL), was synthesized via bulk ring-opening polymerisation (ROP) using a novel tin(II)alkoxide initiator, [Sn(Oct)]2DEG, at 130oC for 48 hrs. The effectiveness of this initiator was compared withthe well-known conventional tin(II) octoateinitiator, Sn(Oct)2. The P(LL-co-CL) copolymersobtained were characterized using a combination of analytical technique including: nuclear magnetic resonance spectroscopy (NMR), differential scanning calorimetry (DSC), thermogravimetry (TG) and gel permeation chromatography (GPC). The P(LL-co-CL) was melt-spun into monofilament fibres of uniform diameter and smooth surface appearance. Modification of the matrix morphology was then built into the as-spun fibresvia a series of controlled off-line annealing and hot-drawing steps.
KW - ε-caprolactone
KW - Absorbablesurgical suture
KW - biomedical applications
KW - L-lactide
KW - melt spinning
KW - ring-opening polymerisation
KW - absorbable surgical suture
UR - http://www.scopus.com/inward/record.url?scp=84903367009&partnerID=8YFLogxK
UR - http://www.scientific.net/AMR.894.172
U2 - 10.4028/www.scientific.net/AMR.894.172
DO - 10.4028/www.scientific.net/AMR.894.172
M3 - Conference publication
AN - SCOPUS:84903367009
SN - 978-3-03835-032-3
T3 - Advanced materials research
SP - 172
EP - 176
BT - Advanced Materials Research IV
A2 - Guo, Zhihua
A2 - Xu, Jie
PB - Scientific.net
T2 - 4th International Conference on Advanced Materials Research
Y2 - 22 January 2014 through 23 January 2014
ER -