Controlled synthesis and processing of a poly(L-lactide-co-ε-caprolactone) copolymer for biomedical use as an absorbable monofilament surgical suture

Sujitra Ruengdechawiwat, Runglawan Somsunan, Robert Molloy, Jintana Siripitayananon, Valerie J. Franklin, Paul D. Topham, Brian J. Tighe

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Poly(L-lactide-co-ε-caprolactone) 75:25% mol, P(LL-co-CL), was synthesized via bulk ring-opening polymerisation (ROP) using a novel tin(II)alkoxide initiator, [Sn(Oct)]2DEG, at 130oC for 48 hrs. The effectiveness of this initiator was compared withthe well-known conventional tin(II) octoateinitiator, Sn(Oct)2. The P(LL-co-CL) copolymersobtained were characterized using a combination of analytical technique including: nuclear magnetic resonance spectroscopy (NMR), differential scanning calorimetry (DSC), thermogravimetry (TG) and gel permeation chromatography (GPC). The P(LL-co-CL) was melt-spun into monofilament fibres of uniform diameter and smooth surface appearance. Modification of the matrix morphology was then built into the as-spun fibresvia a series of controlled off-line annealing and hot-drawing steps.

LanguageEnglish
Title of host publicationAdvanced Materials Research IV
EditorsZhihua Guo, Jie Xu
PublisherScientific.net
Pages172-176
Number of pages5
ISBN (Print)978-3-03835-032-3
DOIs
Publication statusPublished - 19 Mar 2014
Event4th International Conference on Advanced Materials Research - Macau, China
Duration: 22 Jan 201423 Jan 2014

Publication series

NameAdvanced materials research
PublisherScientific.net
Volume894
ISSN (Print)1022-6680

Conference

Conference4th International Conference on Advanced Materials Research
Abbreviated titleICAMR 2014
CountryChina
CityMacau
Period22/01/1423/01/14

Fingerprint

Tin
Copolymers
Two dimensional electron gas
Ring opening polymerization
Gel permeation chromatography
Processing
Nuclear magnetic resonance spectroscopy
Thermogravimetric analysis
Differential scanning calorimetry
Annealing
Fibers

Keywords

  • ε-caprolactone
  • Absorbablesurgical suture
  • biomedical applications
  • L-lactide
  • melt spinning
  • ring-opening polymerisation
  • absorbable surgical suture

Cite this

Ruengdechawiwat, S., Somsunan, R., Molloy, R., Siripitayananon, J., Franklin, V. J., Topham, P. D., & Tighe, B. J. (2014). Controlled synthesis and processing of a poly(L-lactide-co-ε-caprolactone) copolymer for biomedical use as an absorbable monofilament surgical suture. In Z. Guo, & J. Xu (Eds.), Advanced Materials Research IV (pp. 172-176). (Advanced materials research; Vol. 894). Scientific.net. https://doi.org/10.4028/www.scientific.net/AMR.894.172
Ruengdechawiwat, Sujitra ; Somsunan, Runglawan ; Molloy, Robert ; Siripitayananon, Jintana ; Franklin, Valerie J. ; Topham, Paul D. ; Tighe, Brian J. / Controlled synthesis and processing of a poly(L-lactide-co-ε-caprolactone) copolymer for biomedical use as an absorbable monofilament surgical suture. Advanced Materials Research IV. editor / Zhihua Guo ; Jie Xu. Scientific.net, 2014. pp. 172-176 (Advanced materials research).
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abstract = "Poly(L-lactide-co-ε-caprolactone) 75:25{\%} mol, P(LL-co-CL), was synthesized via bulk ring-opening polymerisation (ROP) using a novel tin(II)alkoxide initiator, [Sn(Oct)]2DEG, at 130oC for 48 hrs. The effectiveness of this initiator was compared withthe well-known conventional tin(II) octoateinitiator, Sn(Oct)2. The P(LL-co-CL) copolymersobtained were characterized using a combination of analytical technique including: nuclear magnetic resonance spectroscopy (NMR), differential scanning calorimetry (DSC), thermogravimetry (TG) and gel permeation chromatography (GPC). The P(LL-co-CL) was melt-spun into monofilament fibres of uniform diameter and smooth surface appearance. Modification of the matrix morphology was then built into the as-spun fibresvia a series of controlled off-line annealing and hot-drawing steps.",
keywords = "ε-caprolactone, Absorbablesurgical suture, biomedical applications, L-lactide, melt spinning, ring-opening polymerisation, absorbable surgical suture",
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Ruengdechawiwat, S, Somsunan, R, Molloy, R, Siripitayananon, J, Franklin, VJ, Topham, PD & Tighe, BJ 2014, Controlled synthesis and processing of a poly(L-lactide-co-ε-caprolactone) copolymer for biomedical use as an absorbable monofilament surgical suture. in Z Guo & J Xu (eds), Advanced Materials Research IV. Advanced materials research, vol. 894, Scientific.net, pp. 172-176, 4th International Conference on Advanced Materials Research, Macau, China, 22/01/14. https://doi.org/10.4028/www.scientific.net/AMR.894.172

Controlled synthesis and processing of a poly(L-lactide-co-ε-caprolactone) copolymer for biomedical use as an absorbable monofilament surgical suture. / Ruengdechawiwat, Sujitra; Somsunan, Runglawan; Molloy, Robert; Siripitayananon, Jintana; Franklin, Valerie J.; Topham, Paul D.; Tighe, Brian J.

Advanced Materials Research IV. ed. / Zhihua Guo; Jie Xu. Scientific.net, 2014. p. 172-176 (Advanced materials research; Vol. 894).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

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T1 - Controlled synthesis and processing of a poly(L-lactide-co-ε-caprolactone) copolymer for biomedical use as an absorbable monofilament surgical suture

AU - Ruengdechawiwat, Sujitra

AU - Somsunan, Runglawan

AU - Molloy, Robert

AU - Siripitayananon, Jintana

AU - Franklin, Valerie J.

AU - Topham, Paul D.

AU - Tighe, Brian J.

PY - 2014/3/19

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N2 - Poly(L-lactide-co-ε-caprolactone) 75:25% mol, P(LL-co-CL), was synthesized via bulk ring-opening polymerisation (ROP) using a novel tin(II)alkoxide initiator, [Sn(Oct)]2DEG, at 130oC for 48 hrs. The effectiveness of this initiator was compared withthe well-known conventional tin(II) octoateinitiator, Sn(Oct)2. The P(LL-co-CL) copolymersobtained were characterized using a combination of analytical technique including: nuclear magnetic resonance spectroscopy (NMR), differential scanning calorimetry (DSC), thermogravimetry (TG) and gel permeation chromatography (GPC). The P(LL-co-CL) was melt-spun into monofilament fibres of uniform diameter and smooth surface appearance. Modification of the matrix morphology was then built into the as-spun fibresvia a series of controlled off-line annealing and hot-drawing steps.

AB - Poly(L-lactide-co-ε-caprolactone) 75:25% mol, P(LL-co-CL), was synthesized via bulk ring-opening polymerisation (ROP) using a novel tin(II)alkoxide initiator, [Sn(Oct)]2DEG, at 130oC for 48 hrs. The effectiveness of this initiator was compared withthe well-known conventional tin(II) octoateinitiator, Sn(Oct)2. The P(LL-co-CL) copolymersobtained were characterized using a combination of analytical technique including: nuclear magnetic resonance spectroscopy (NMR), differential scanning calorimetry (DSC), thermogravimetry (TG) and gel permeation chromatography (GPC). The P(LL-co-CL) was melt-spun into monofilament fibres of uniform diameter and smooth surface appearance. Modification of the matrix morphology was then built into the as-spun fibresvia a series of controlled off-line annealing and hot-drawing steps.

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KW - Absorbablesurgical suture

KW - biomedical applications

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KW - melt spinning

KW - ring-opening polymerisation

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DO - 10.4028/www.scientific.net/AMR.894.172

M3 - Conference contribution

SN - 978-3-03835-032-3

T3 - Advanced materials research

SP - 172

EP - 176

BT - Advanced Materials Research IV

A2 - Guo, Zhihua

A2 - Xu, Jie

PB - Scientific.net

ER -

Ruengdechawiwat S, Somsunan R, Molloy R, Siripitayananon J, Franklin VJ, Topham PD et al. Controlled synthesis and processing of a poly(L-lactide-co-ε-caprolactone) copolymer for biomedical use as an absorbable monofilament surgical suture. In Guo Z, Xu J, editors, Advanced Materials Research IV. Scientific.net. 2014. p. 172-176. (Advanced materials research). https://doi.org/10.4028/www.scientific.net/AMR.894.172