Depression and tetrahydrobiopterin: the folate connection

A. Coppen, C. Swade, S.A. Jones, Richard A. Armstrong, J.A. Blair, R.J. Leeming

Research output: Contribution to journalArticle

Abstract

Total biopterin, neopterin and creatinine were measured in spot urine samples from affective disorder patients on lithium therapy and control subjects. Folic acid was also measured in plasma in a sample of the patients. The mean neopterin: biopterin ratio was significantly higher in the 76 patients (3.2 +/- 0.5) than in the 61 controls (1.8 +/- 0.1). In female patients biopterin levels were significantly lower than in controls. In the control groups there was a significant correlation between the molar concentration of neopterin and biopterin. No such correlation was found in the patients. These data indicate that tetrahydrobiopterin (BH4) biosynthesis is reduced in this group. A significant positive correlation was found between plasma folate and urinary biopterin. It is suggested that folate deficiency may impair the synthesis of BH4, a cofactor essential for the synthesis of 5-HT and other monoamines that are involved in the pathogenesis of affective disorders.
Original languageEnglish
Pages (from-to)103-107
Number of pages5
JournalJournal of Affective Disorders
Volume16
Issue number2-3
DOIs
Publication statusPublished - Mar 1989

Fingerprint

Biopterin
Folic Acid
Neopterin
Depression
Mood Disorders
Lithium
Creatinine
Serotonin
sapropterin
Urine
Control Groups

Keywords

  • Tetrahydrobiopterin
  • neopterin
  • depression
  • folic acid
  • monoamines

Cite this

Coppen, A., Swade, C., Jones, S. A., Armstrong, R. A., Blair, J. A., & Leeming, R. J. (1989). Depression and tetrahydrobiopterin: the folate connection. Journal of Affective Disorders, 16(2-3), 103-107. https://doi.org/10.1016/0165-0327(89)90062-1
Coppen, A. ; Swade, C. ; Jones, S.A. ; Armstrong, Richard A. ; Blair, J.A. ; Leeming, R.J. / Depression and tetrahydrobiopterin: the folate connection. In: Journal of Affective Disorders. 1989 ; Vol. 16, No. 2-3. pp. 103-107.
@article{50e0cc3ea1fb46e3b175e0eb150d14f4,
title = "Depression and tetrahydrobiopterin: the folate connection",
abstract = "Total biopterin, neopterin and creatinine were measured in spot urine samples from affective disorder patients on lithium therapy and control subjects. Folic acid was also measured in plasma in a sample of the patients. The mean neopterin: biopterin ratio was significantly higher in the 76 patients (3.2 +/- 0.5) than in the 61 controls (1.8 +/- 0.1). In female patients biopterin levels were significantly lower than in controls. In the control groups there was a significant correlation between the molar concentration of neopterin and biopterin. No such correlation was found in the patients. These data indicate that tetrahydrobiopterin (BH4) biosynthesis is reduced in this group. A significant positive correlation was found between plasma folate and urinary biopterin. It is suggested that folate deficiency may impair the synthesis of BH4, a cofactor essential for the synthesis of 5-HT and other monoamines that are involved in the pathogenesis of affective disorders.",
keywords = "Tetrahydrobiopterin, neopterin, depression, folic acid, monoamines",
author = "A. Coppen and C. Swade and S.A. Jones and Armstrong, {Richard A.} and J.A. Blair and R.J. Leeming",
year = "1989",
month = "3",
doi = "10.1016/0165-0327(89)90062-1",
language = "English",
volume = "16",
pages = "103--107",
journal = "Journal of Affective Disorders",
issn = "0165-0327",
publisher = "Elsevier",
number = "2-3",

}

Coppen, A, Swade, C, Jones, SA, Armstrong, RA, Blair, JA & Leeming, RJ 1989, 'Depression and tetrahydrobiopterin: the folate connection', Journal of Affective Disorders, vol. 16, no. 2-3, pp. 103-107. https://doi.org/10.1016/0165-0327(89)90062-1

Depression and tetrahydrobiopterin: the folate connection. / Coppen, A.; Swade, C.; Jones, S.A.; Armstrong, Richard A.; Blair, J.A.; Leeming, R.J.

In: Journal of Affective Disorders, Vol. 16, No. 2-3, 03.1989, p. 103-107.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Depression and tetrahydrobiopterin: the folate connection

AU - Coppen, A.

AU - Swade, C.

AU - Jones, S.A.

AU - Armstrong, Richard A.

AU - Blair, J.A.

AU - Leeming, R.J.

PY - 1989/3

Y1 - 1989/3

N2 - Total biopterin, neopterin and creatinine were measured in spot urine samples from affective disorder patients on lithium therapy and control subjects. Folic acid was also measured in plasma in a sample of the patients. The mean neopterin: biopterin ratio was significantly higher in the 76 patients (3.2 +/- 0.5) than in the 61 controls (1.8 +/- 0.1). In female patients biopterin levels were significantly lower than in controls. In the control groups there was a significant correlation between the molar concentration of neopterin and biopterin. No such correlation was found in the patients. These data indicate that tetrahydrobiopterin (BH4) biosynthesis is reduced in this group. A significant positive correlation was found between plasma folate and urinary biopterin. It is suggested that folate deficiency may impair the synthesis of BH4, a cofactor essential for the synthesis of 5-HT and other monoamines that are involved in the pathogenesis of affective disorders.

AB - Total biopterin, neopterin and creatinine were measured in spot urine samples from affective disorder patients on lithium therapy and control subjects. Folic acid was also measured in plasma in a sample of the patients. The mean neopterin: biopterin ratio was significantly higher in the 76 patients (3.2 +/- 0.5) than in the 61 controls (1.8 +/- 0.1). In female patients biopterin levels were significantly lower than in controls. In the control groups there was a significant correlation between the molar concentration of neopterin and biopterin. No such correlation was found in the patients. These data indicate that tetrahydrobiopterin (BH4) biosynthesis is reduced in this group. A significant positive correlation was found between plasma folate and urinary biopterin. It is suggested that folate deficiency may impair the synthesis of BH4, a cofactor essential for the synthesis of 5-HT and other monoamines that are involved in the pathogenesis of affective disorders.

KW - Tetrahydrobiopterin

KW - neopterin

KW - depression

KW - folic acid

KW - monoamines

UR - https://www.sciencedirect.com/science/article/pii/0165032789900621?via%3Dihub

U2 - 10.1016/0165-0327(89)90062-1

DO - 10.1016/0165-0327(89)90062-1

M3 - Article

VL - 16

SP - 103

EP - 107

JO - Journal of Affective Disorders

JF - Journal of Affective Disorders

SN - 0165-0327

IS - 2-3

ER -

Coppen A, Swade C, Jones SA, Armstrong RA, Blair JA, Leeming RJ. Depression and tetrahydrobiopterin: the folate connection. Journal of Affective Disorders. 1989 Mar;16(2-3):103-107. https://doi.org/10.1016/0165-0327(89)90062-1