TY - GEN
T1 - Design and preparation of a bioresponsive hydrogel for biomedical application as a wound dressing
AU - Witthayaprapakorn, C.
AU - Molloy, R.
AU - Nalampang, K.
AU - Tighe, B. J.
PY - 2008/12/1
Y1 - 2008/12/1
N2 - In this work, the sodium salt of 2-acrylamido-2-methylpropanesulfonic acid (Na-AMPS) was photopolymerised in aqueous solution with ethylene glycol dimethacrylate (EGDM) added as a crosslinking agent and 4,4'-azo-bis(4- cyanopentanoic acid) as the water-soluble photoinitiator. The aqueous solution was poured into a vertical sheet-forming mould consisting of two parallel plates covered with Teflon® sheets as release liners. Spacers were used to control the sheet thickness with a polymer mesh inserted in the middle to strengthen the hydrogel. The hydrogel sheets obtained were of 1.2 ± 0.2 mm thickness and showed good transparency, flexibility and skin adhesion. On immersion in distilled water at 37°C, it was found that the equilibrium water content (EWC) reached 98 ± 1% within 20 mins following which the equilibrium water retention (EWR) in ambient air was 21 ± 1% over a period of about 4 hrs. The water vapour transmission rate (WVTR) was measured at 37 °C and was found to be 82 ± 2 g m
-2 hr
-1. It is concluded that this Na-AMPS hydrogel sheet has properties which show potential for biomedical use as a wound dressing.
AB - In this work, the sodium salt of 2-acrylamido-2-methylpropanesulfonic acid (Na-AMPS) was photopolymerised in aqueous solution with ethylene glycol dimethacrylate (EGDM) added as a crosslinking agent and 4,4'-azo-bis(4- cyanopentanoic acid) as the water-soluble photoinitiator. The aqueous solution was poured into a vertical sheet-forming mould consisting of two parallel plates covered with Teflon® sheets as release liners. Spacers were used to control the sheet thickness with a polymer mesh inserted in the middle to strengthen the hydrogel. The hydrogel sheets obtained were of 1.2 ± 0.2 mm thickness and showed good transparency, flexibility and skin adhesion. On immersion in distilled water at 37°C, it was found that the equilibrium water content (EWC) reached 98 ± 1% within 20 mins following which the equilibrium water retention (EWR) in ambient air was 21 ± 1% over a period of about 4 hrs. The water vapour transmission rate (WVTR) was measured at 37 °C and was found to be 82 ± 2 g m
-2 hr
-1. It is concluded that this Na-AMPS hydrogel sheet has properties which show potential for biomedical use as a wound dressing.
KW - Hydrogel wound dressing
KW - Photopolymerisation
KW - Sodium AMPS
UR - http://www.scopus.com/inward/record.url?scp=62949182277&partnerID=8YFLogxK
M3 - Conference publication
AN - SCOPUS:62949182277
SN - 9780878493562
VL - 55-57
T3 - Advanced Materials Research
SP - 681
EP - 684
BT - Advanced Materials Research
ER -