Design and preparation of a bioresponsive hydrogel for biomedical application as a wound dressing

C. Witthayaprapakorn*, R. Molloy, K. Nalampang, B. J. Tighe

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

In this work, the sodium salt of 2-acrylamido-2-methylpropanesulfonic acid (Na-AMPS) was photopolymerised in aqueous solution with ethylene glycol dimethacrylate (EGDM) added as a crosslinking agent and 4,4'-azo-bis(4- cyanopentanoic acid) as the water-soluble photoinitiator. The aqueous solution was poured into a vertical sheet-forming mould consisting of two parallel plates covered with Teflon® sheets as release liners. Spacers were used to control the sheet thickness with a polymer mesh inserted in the middle to strengthen the hydrogel. The hydrogel sheets obtained were of 1.2 ± 0.2 mm thickness and showed good transparency, flexibility and skin adhesion. On immersion in distilled water at 37°C, it was found that the equilibrium water content (EWC) reached 98 ± 1% within 20 mins following which the equilibrium water retention (EWR) in ambient air was 21 ± 1% over a period of about 4 hrs. The water vapour transmission rate (WVTR) was measured at 37 °C and was found to be 82 ± 2 g m -2 hr -1. It is concluded that this Na-AMPS hydrogel sheet has properties which show potential for biomedical use as a wound dressing.

Original languageEnglish
Title of host publicationAdvanced Materials Research
Pages681-684
Number of pages4
Volume55-57
Publication statusPublished - 1 Dec 2008

Publication series

NameAdvanced Materials Research
Volume55-57
ISSN (Print)10226680

Fingerprint

Hydrogels
Water
Acids
Ethylene glycol
Polytetrafluoroethylenes
Crosslinking
Transparency
Water vapor
Water content
Skin
Adhesion
Sodium
Salts
Polymers
Air

Keywords

  • Hydrogel wound dressing
  • Photopolymerisation
  • Sodium AMPS

Cite this

Witthayaprapakorn, C., Molloy, R., Nalampang, K., & Tighe, B. J. (2008). Design and preparation of a bioresponsive hydrogel for biomedical application as a wound dressing. In Advanced Materials Research (Vol. 55-57, pp. 681-684). (Advanced Materials Research; Vol. 55-57).
Witthayaprapakorn, C. ; Molloy, R. ; Nalampang, K. ; Tighe, B. J. / Design and preparation of a bioresponsive hydrogel for biomedical application as a wound dressing. Advanced Materials Research. Vol. 55-57 2008. pp. 681-684 (Advanced Materials Research).
@inproceedings{d366a7ecfc8e4d9fa181b3cdc46b1536,
title = "Design and preparation of a bioresponsive hydrogel for biomedical application as a wound dressing",
abstract = "In this work, the sodium salt of 2-acrylamido-2-methylpropanesulfonic acid (Na-AMPS) was photopolymerised in aqueous solution with ethylene glycol dimethacrylate (EGDM) added as a crosslinking agent and 4,4'-azo-bis(4- cyanopentanoic acid) as the water-soluble photoinitiator. The aqueous solution was poured into a vertical sheet-forming mould consisting of two parallel plates covered with Teflon{\circledR} sheets as release liners. Spacers were used to control the sheet thickness with a polymer mesh inserted in the middle to strengthen the hydrogel. The hydrogel sheets obtained were of 1.2 ± 0.2 mm thickness and showed good transparency, flexibility and skin adhesion. On immersion in distilled water at 37°C, it was found that the equilibrium water content (EWC) reached 98 ± 1{\%} within 20 mins following which the equilibrium water retention (EWR) in ambient air was 21 ± 1{\%} over a period of about 4 hrs. The water vapour transmission rate (WVTR) was measured at 37 °C and was found to be 82 ± 2 g m -2 hr -1. It is concluded that this Na-AMPS hydrogel sheet has properties which show potential for biomedical use as a wound dressing.",
keywords = "Hydrogel wound dressing, Photopolymerisation, Sodium AMPS",
author = "C. Witthayaprapakorn and R. Molloy and K. Nalampang and Tighe, {B. J.}",
year = "2008",
month = "12",
day = "1",
language = "English",
isbn = "9780878493562",
volume = "55-57",
series = "Advanced Materials Research",
pages = "681--684",
booktitle = "Advanced Materials Research",

}

Witthayaprapakorn, C, Molloy, R, Nalampang, K & Tighe, BJ 2008, Design and preparation of a bioresponsive hydrogel for biomedical application as a wound dressing. in Advanced Materials Research. vol. 55-57, Advanced Materials Research, vol. 55-57, pp. 681-684.

Design and preparation of a bioresponsive hydrogel for biomedical application as a wound dressing. / Witthayaprapakorn, C.; Molloy, R.; Nalampang, K.; Tighe, B. J.

Advanced Materials Research. Vol. 55-57 2008. p. 681-684 (Advanced Materials Research; Vol. 55-57).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

TY - GEN

T1 - Design and preparation of a bioresponsive hydrogel for biomedical application as a wound dressing

AU - Witthayaprapakorn, C.

AU - Molloy, R.

AU - Nalampang, K.

AU - Tighe, B. J.

PY - 2008/12/1

Y1 - 2008/12/1

N2 - In this work, the sodium salt of 2-acrylamido-2-methylpropanesulfonic acid (Na-AMPS) was photopolymerised in aqueous solution with ethylene glycol dimethacrylate (EGDM) added as a crosslinking agent and 4,4'-azo-bis(4- cyanopentanoic acid) as the water-soluble photoinitiator. The aqueous solution was poured into a vertical sheet-forming mould consisting of two parallel plates covered with Teflon® sheets as release liners. Spacers were used to control the sheet thickness with a polymer mesh inserted in the middle to strengthen the hydrogel. The hydrogel sheets obtained were of 1.2 ± 0.2 mm thickness and showed good transparency, flexibility and skin adhesion. On immersion in distilled water at 37°C, it was found that the equilibrium water content (EWC) reached 98 ± 1% within 20 mins following which the equilibrium water retention (EWR) in ambient air was 21 ± 1% over a period of about 4 hrs. The water vapour transmission rate (WVTR) was measured at 37 °C and was found to be 82 ± 2 g m -2 hr -1. It is concluded that this Na-AMPS hydrogel sheet has properties which show potential for biomedical use as a wound dressing.

AB - In this work, the sodium salt of 2-acrylamido-2-methylpropanesulfonic acid (Na-AMPS) was photopolymerised in aqueous solution with ethylene glycol dimethacrylate (EGDM) added as a crosslinking agent and 4,4'-azo-bis(4- cyanopentanoic acid) as the water-soluble photoinitiator. The aqueous solution was poured into a vertical sheet-forming mould consisting of two parallel plates covered with Teflon® sheets as release liners. Spacers were used to control the sheet thickness with a polymer mesh inserted in the middle to strengthen the hydrogel. The hydrogel sheets obtained were of 1.2 ± 0.2 mm thickness and showed good transparency, flexibility and skin adhesion. On immersion in distilled water at 37°C, it was found that the equilibrium water content (EWC) reached 98 ± 1% within 20 mins following which the equilibrium water retention (EWR) in ambient air was 21 ± 1% over a period of about 4 hrs. The water vapour transmission rate (WVTR) was measured at 37 °C and was found to be 82 ± 2 g m -2 hr -1. It is concluded that this Na-AMPS hydrogel sheet has properties which show potential for biomedical use as a wound dressing.

KW - Hydrogel wound dressing

KW - Photopolymerisation

KW - Sodium AMPS

UR - http://www.scopus.com/inward/record.url?scp=62949182277&partnerID=8YFLogxK

M3 - Conference contribution

AN - SCOPUS:62949182277

SN - 9780878493562

VL - 55-57

T3 - Advanced Materials Research

SP - 681

EP - 684

BT - Advanced Materials Research

ER -

Witthayaprapakorn C, Molloy R, Nalampang K, Tighe BJ. Design and preparation of a bioresponsive hydrogel for biomedical application as a wound dressing. In Advanced Materials Research. Vol. 55-57. 2008. p. 681-684. (Advanced Materials Research).