Design, synthesis and evaluation of a fluorescent peptidyl sensor for the selective recognition of arsenite

Katy J. Parker; Sanjeev Kumar; Dierdre A. Pearce; Andrew J. Sutherland

doi:10.1016/j.tetlet.2005.08.058

Design, synthesis and evaluation of a fluorescent peptidyl sensor for the selective recognition of arsenite

Katy J. Parker, Sanjeev Kumar, Dierdre A. Pearce, Andrew J. Sutherland^*

^*Corresponding author for this work

Chemical Engineering & Applied Chemistry

Research output: Contribution to journal › Article › peer-review

Abstract

A series of fluorescently labelled phytochelatin-like peptide sequences has been designed and synthesised as molecules with the ability both to bind to arsenite and to report this binding event. The peptides have been evaluated against a panel of biologically significant ions. The results of these initial studies are reported herein, and a structure which displays selectivity for As(III) over As(V) and other anions has been identified.

Original language	English
Pages (from-to)	7043-7045
Number of pages	3
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	46
Issue number	41
DOIs	https://doi.org/10.1016/j.tetlet.2005.08.058
Publication status	Published - 10 Oct 2005

Keywords

Arsenic
Arsenite
Fluorescence
Peptide sensor

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10.1016/j.tetlet.2005.08.058

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title = "Design, synthesis and evaluation of a fluorescent peptidyl sensor for the selective recognition of arsenite",

abstract = "A series of fluorescently labelled phytochelatin-like peptide sequences has been designed and synthesised as molecules with the ability both to bind to arsenite and to report this binding event. The peptides have been evaluated against a panel of biologically significant ions. The results of these initial studies are reported herein, and a structure which displays selectivity for As(III) over As(V) and other anions has been identified.",

keywords = "Arsenic, Arsenite, Fluorescence, Peptide sensor",

author = "Parker, {Katy J.} and Sanjeev Kumar and Pearce, {Dierdre A.} and Sutherland, {Andrew J.}",

year = "2005",

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doi = "10.1016/j.tetlet.2005.08.058",

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T1 - Design, synthesis and evaluation of a fluorescent peptidyl sensor for the selective recognition of arsenite

AU - Parker, Katy J.

AU - Kumar, Sanjeev

AU - Pearce, Dierdre A.

AU - Sutherland, Andrew J.

PY - 2005/10/10

Y1 - 2005/10/10

N2 - A series of fluorescently labelled phytochelatin-like peptide sequences has been designed and synthesised as molecules with the ability both to bind to arsenite and to report this binding event. The peptides have been evaluated against a panel of biologically significant ions. The results of these initial studies are reported herein, and a structure which displays selectivity for As(III) over As(V) and other anions has been identified.

AB - A series of fluorescently labelled phytochelatin-like peptide sequences has been designed and synthesised as molecules with the ability both to bind to arsenite and to report this binding event. The peptides have been evaluated against a panel of biologically significant ions. The results of these initial studies are reported herein, and a structure which displays selectivity for As(III) over As(V) and other anions has been identified.

KW - Arsenic

KW - Arsenite

KW - Fluorescence

KW - Peptide sensor

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UR - https://www.sciencedirect.com/science/article/pii/S0040403905017910?via%3Dihub

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M3 - Article

AN - SCOPUS:24344491156

SN - 1464-3405

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SP - 7043

EP - 7045

JO - Bioorganic and Medicinal Chemistry Letters

JF - Bioorganic and Medicinal Chemistry Letters

IS - 41

ER -

Design, synthesis and evaluation of a fluorescent peptidyl sensor for the selective recognition of arsenite

Abstract

Keywords

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