Differential activation in temporal, cingulate and prefrontal cortices during response inhibition in bipolar disorder

Stefanie Hassel, Glenda M. MacQueen

Research output: Contribution to journalConference abstract

Abstract

Background: Increased impulsivity and aberrant response inhibition have been observed in bipolar disorder (BD). This study examined the functional abnormalities and underlying neural processes during response inhibition in BD, and its relationship to impulsivity.
Methods: We assessed impulsivity using the Barratt Impulsiveness Scale (BIS) and, using functional magnetic resonance imaging (fMRI), measured neural activity in response to an Affective Go-NoGo Task, consisting of emotional facial stimuli (fear, happy, anger faces) and non-emotional control stimuli (neutral female and male faces) in euthymic BD (n=23) and healthy individuals (HI; n=25).
Results: BD patients were significantly more impulsive, yet did not differ from HI on accuracy or reaction time on the emotional go/no-go task. Comparing neural patterns of activation when processing emotional Go versus emotional NoGo trials yielded increased activation in BD within temporal and cingulate cortices and within prefrontal-cortical regions in HI. Furthermore, higher BIS scores for BD were associated with slower reaction times, and indicative of compensatory cognitive strategies to counter increased impulsivity.
Conclusions: These findings illustrate cognition-emotion interference in BD and the observed differences in neural activation indicate potentially altered emotion modulation. Increased activation in brain regions previously shown in emotion regulation and response inhibition tasks could represent a disease-specific marker for BD
Original languageEnglish
Article number539
Pages (from-to)194S
Number of pages1
JournalBiological Psychiatry
Volume77
Issue number9 Suppl.
Early online date3 Apr 2015
DOIs
Publication statusPublished - 1 May 2015
Event70th Annual Scientific Meeting of the Society of Biological Psychiatry on Stress, Emotion, Neurodevelopment and Psychopathology - Toronto, Canada
Duration: 14 May 201516 May 2015

Bibliographical note

Friday abstracts: 70th Annual Scientific Meeting of the Society of Biological Psychiatry on Stress, Emotion, Neurodevelopment and Psychopathology, 14-16 May 2015, Toronto (CA).

Keywords

  • bipolar disorder
  • response inhibition
  • affect recognition
  • impulsivity
  • functional magnetic resonance imaging

Fingerprint Dive into the research topics of 'Differential activation in temporal, cingulate and prefrontal cortices during response inhibition in bipolar disorder'. Together they form a unique fingerprint.

  • Research Output

    • 1 Conference abstract

    Facial affect processing inbipolar disorder: a magnetoencephalography study

    Hassel, S., Sharma, G. B., Castellanos, L., Bagic, A., Kass, R. E. & Phillips, M. L., 1 May 2015, In : Biological Psychiatry. 77, 9 Supp.1, p. 382S 1 p., 1051.

    Research output: Contribution to journalConference abstract

  • Cite this