Dissolution rate enhancement, in vitro evaluation and investigation of drug release kinetics of chloramphenicol and sulphamethoxazole solid dispersions

Sheraz Khan, Hannah Batchelor, Peter Hanson, Imran Y. Saleem, Yvonne Perrie, Afzal R. Mohammed

Research output: Contribution to journalArticle

Abstract

Formulation of solid dispersions is one of the effective methods to increase the rate of solubilization and dissolution of poorly soluble drugs. Solid dispersions of chloramphenicol (CP) and sulphamethoxazole (SX) as model drugs were prepared by melt fusion method using polyethylene glycol 8000 (PEG 8000) as an inert carrier. The dissolution rate of CP and SX were rapid from solid dispersions with low drug and high polymer content. Characterization was performed using fourier transform infrared spectroscopy (FTIR), differential scanning calorimetry (DSC) and scanning electron microscopy (SEM). FTIR analysis for the solid dispersions of CP and SX showed that there was no interaction between PEG 8000 and the drugs. Hyper-DSC studies revealed that CP and SX were converted into an amorphous form when formulated as solid dispersion in PEG 8000. Mathematical analysis of the release kinetics demonstrated that drug release from the various formulations followed different mechanisms. Permeability studies demonstrated that both CP and SX when formulated as solid dispersions showed enhanced permeability across Caco-2 cells and CP can be classified as well-absorbed compound when formulated as solid dispersions. © 2013 Informa Healthcare USA, Inc.
Original languageEnglish
Pages (from-to)704-715
Number of pages12
JournalDrug Development and Industrial Pharmacy
Volume39
Issue number5
Early online date29 May 2012
DOIs
Publication statusPublished - May 2013

Fingerprint

Sulfamethoxazole
Chloramphenicol
Dispersions
Dissolution
Pharmacokinetics
Kinetics
Pharmaceutical Preparations
Differential Scanning Calorimetry
Fourier Transform Infrared Spectroscopy
Permeability
Differential scanning calorimetry
Caco-2 Cells
Electron Scanning Microscopy
In Vitro Techniques
Drug Liberation
Polymers
Fusion reactions
Delivery of Health Care
Scanning electron microscopy
polyethylene glycol 8000

Cite this

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Dissolution rate enhancement, in vitro evaluation and investigation of drug release kinetics of chloramphenicol and sulphamethoxazole solid dispersions. / Khan, Sheraz; Batchelor, Hannah; Hanson, Peter; Saleem, Imran Y.; Perrie, Yvonne; Mohammed, Afzal R.

In: Drug Development and Industrial Pharmacy, Vol. 39, No. 5, 05.2013, p. 704-715.

Research output: Contribution to journalArticle

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AU - Perrie, Yvonne

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