Dosage form preference consultation study in children and young adults: paving the way for patient-centred and patient-informed dosage form development

Hamad Alyami, Eman Dahmash, Fahad Alyami, Dania Dahmash, Chi Huynh, David Terry, Afzal R. Mohammed

Research output: Contribution to journalArticle

Abstract

Objectives: The current study aims to evaluate dosage form preferences in children and young adults together with identifying the key pragmatic dosage form characteristics that would enable appropriate formulation of orally disintegrating tablets (ODTs).
Methods: International, multisite, cross-sectional questionnaire of children and young adults aged from 6 to 18 years. Eligibility was based on age, ability to communicate and previous experience in taking medications. The study was carried out at three locations: the UK, Saudi Arabia and Jordan. The questionnaire instrument was designed for participant self-completion under supervision of the study team.Results 104 questionnaires were completed by the study cohort (n=120, response rate 87%).
Results: showed that ODTs were the most preferred oral dosage forms (58%) followed by liquids (20%), tablets (12%) and capsules (11%). The preferred colours were pink or white while the preferred size was small (<8 mm) with a round shape. With regard to flavour, strawberry was the most preferred (30.8%), while orange was the least preferred (5.8%). The results also showed that the most important physical characteristics of ODTs were disintegration time followed by taste, size and flavour, respectively.
Conclusions: The results of our study support the WHO's claim for a shift of paradigm from liquid towards ODTs dosage forms for drug administration to young children older than 6 years. Data from this study will also equip formulators to prioritise development of key physical/performance attributes within the delivery system.
Original languageEnglish
Pages (from-to)332-337
JournalEuropean Journal of Hospital Pharmacy
Volume24
Early online date2 Sep 2016
DOIs
Publication statusPublished - 26 Oct 2017

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