Effect of cancer cachexia on triacylglycerol/fatty acid substrate cycling in white adipose tissue

S.A. Beck, M.J. Tisdale*

*Corresponding author for this work

Research output: Contribution to journalArticle

Abstract

The effect of cancer cachexia on the TAG/FA substrate cycle in white adipose tissue was determined in vivo using the MAC16 murine model of cachexia. When compared with non-tumor-bearing animals, the rate of TAG-glycerol production was found to be increased almost threefold in animals bearing the MAC13 tumor, which does not induce cachexia, but was not further elevated in animals bearing the MAC16 tumor. In both cases TAG-glycerol production and de novo synthesis of TAG-FA were also increased above non-tumor-bearing animals. In animals bearing the MAC16 tumor, the TAG-FA rates were significantly higher than in animals bearing the MAC13 tumor. This suggests that the presence of the tumor alone is sufficient to cause an increase in cycling rate, and in the absence of an elevated energy intake (MAC16) this may contribute to the depletion of adipose tissue.

Original languageEnglish
Article numberL9569
Pages (from-to)1187-1189
Number of pages3
JournalLipids
Volume39
Issue number12
DOIs
Publication statusPublished - Dec 2004

Keywords

  • cancer cachexia
  • TAG/FA substrate cycle
  • white adipose tissue
  • adipose tissue

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