Effects of ball-milling on PLGA polymer and its implication on lansoprazole-loaded nanoparticles

Anjumn Shabir, Farhan Alhusban, Yvonne Perrie, Afzal R. Mohammed

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Abstract

PLGA is a biodegradable polymer utilised widely in pharmaceutical research for the encapsulation of a wide range of drugs as nano particulate systems. This study investigates the impact of rotary ball milling on the physical properties of PLGA and its influence on nanoparticle formation prepared using the solvent displacement technique. By applying mechanical stress to the polymer and altering its physical appearance and molecular weight, the loading of lansoprazole within the nanoparticles was increased to 96%, with a reduction in particle size. The results indicate that rotary ball milling significantly reduces particle size, increases lansoprazole loading and improves the release profile for lansoprazole loaded PLGA nanoparticles.
Original languageEnglish
Pages (from-to)71-82
Number of pages12
JournalJournal of Basic and Clinical Pharmacy
Volume2
Issue number2
Publication statusPublished - Mar 2011

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