Effects of ball-milling on PLGA polymer and its implication on lansoprazole-loaded nanoparticles

Anjumn Shabir, Farhan Alhusban, Yvonne Perrie, Afzal R. Mohammed

Research output: Contribution to journalArticle

Abstract

PLGA is a biodegradable polymer utilised widely in pharmaceutical research for the encapsulation of a wide range of drugs as nano particulate systems. This study investigates the impact of rotary ball milling on the physical properties of PLGA and its influence on nanoparticle formation prepared using the solvent displacement technique. By applying mechanical stress to the polymer and altering its physical appearance and molecular weight, the loading of lansoprazole within the nanoparticles was increased to 96%, with a reduction in particle size. The results indicate that rotary ball milling significantly reduces particle size, increases lansoprazole loading and improves the release profile for lansoprazole loaded PLGA nanoparticles.
LanguageEnglish
Pages71-82
Number of pages12
JournalJournal of Basic and Clinical Pharmacy
Volume2
Issue number2
Publication statusPublished - Mar 2011

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Lansoprazole
Nanoparticles
Polymers
Particle Size
Mechanical Stress
Molecular Weight
Pharmaceutical Preparations
polylactic acid-polyglycolic acid copolymer

Bibliographical note

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Cite this

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Effects of ball-milling on PLGA polymer and its implication on lansoprazole-loaded nanoparticles. / Shabir, Anjumn; Alhusban, Farhan; Perrie, Yvonne; Mohammed, Afzal R.

In: Journal of Basic and Clinical Pharmacy, Vol. 2, No. 2, 03.2011, p. 71-82.

Research output: Contribution to journalArticle

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