Elevated striatal and decreased dorsolateral prefrontal cortical activity in response to emotional stimuli in euthymic bipolar disorder: no associations with psychotropic medication load

Stefanie Hassel, Jorge R.C. Almeida, Natalie Kerr, Sharon A. Nau, Cecile D. Ladouceur, Kate Fissell, David J. Kupfer, Mary L. Phillips

Research output: Contribution to journalArticle

Abstract

To examine abnormal patterns of frontal cortical-subcortical activity in response to emotional stimuli in euthymic individuals with bipolar disorder type I in order to identify trait-like, pathophysiologic mechanisms of the disorder. We examined potential confounding effects of total psychotropic medication load and illness variables upon neural abnormalities.
Original languageEnglish
Pages (from-to)916-927
Number of pages12
JournalBipolar Disorders
Volume10
Issue number8
Early online date18 Nov 2008
DOIs
Publication statusPublished - Dec 2008

Keywords

  • magnetic resonance imaging
  • emotions
  • computer-assisted image interpretation
  • arousal
  • bipolar disorder
  • humans international agencies receptors
  • psychotropic drugs
  • corpus striatum
  • prefrontal cortex
  • cerebral dominance
  • limbic system
  • nerve net
  • comorbidity
  • cerebral cortex
  • combination drug therapy
  • oxygen
  • facial expression
  • brain mapping
  • visual pattern recognition
  • adult
  • middle aged
  • amygdala
  • male
  • female
  • emotion processing
  • functional MRI

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