Elevated striatal and decreased dorsolateral prefrontal cortical activity in response to emotional stimuli in euthymic bipolar disorder: no associations with psychotropic medication load

Stefanie Hassel, Jorge R.C. Almeida, Natalie Kerr, Sharon A. Nau, Cecile D. Ladouceur, Kate Fissell, David J. Kupfer, Mary L. Phillips

Research output: Contribution to journalArticle

Abstract

To examine abnormal patterns of frontal cortical-subcortical activity in response to emotional stimuli in euthymic individuals with bipolar disorder type I in order to identify trait-like, pathophysiologic mechanisms of the disorder. We examined potential confounding effects of total psychotropic medication load and illness variables upon neural abnormalities.
Original languageEnglish
Pages (from-to)916-927
Number of pages12
JournalBipolar Disorders
Volume10
Issue number8
Early online date18 Nov 2008
DOIs
Publication statusPublished - Dec 2008

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Keywords

  • magnetic resonance imaging
  • emotions
  • computer-assisted image interpretation
  • arousal
  • bipolar disorder
  • humans international agencies receptors
  • psychotropic drugs
  • corpus striatum
  • prefrontal cortex
  • cerebral dominance
  • limbic system
  • nerve net
  • comorbidity
  • cerebral cortex
  • combination drug therapy
  • oxygen
  • facial expression
  • brain mapping
  • visual pattern recognition
  • adult
  • middle aged
  • amygdala
  • male
  • female
  • emotion processing
  • functional MRI

Cite this

Hassel, Stefanie ; Almeida, Jorge R.C. ; Kerr, Natalie ; Nau, Sharon A. ; Ladouceur, Cecile D. ; Fissell, Kate ; Kupfer, David J. ; Phillips, Mary L. / Elevated striatal and decreased dorsolateral prefrontal cortical activity in response to emotional stimuli in euthymic bipolar disorder : no associations with psychotropic medication load. In: Bipolar Disorders. 2008 ; Vol. 10, No. 8. pp. 916-927.
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Elevated striatal and decreased dorsolateral prefrontal cortical activity in response to emotional stimuli in euthymic bipolar disorder : no associations with psychotropic medication load. / Hassel, Stefanie; Almeida, Jorge R.C.; Kerr, Natalie; Nau, Sharon A.; Ladouceur, Cecile D.; Fissell, Kate; Kupfer, David J.; Phillips, Mary L.

In: Bipolar Disorders, Vol. 10, No. 8, 12.2008, p. 916-927.

Research output: Contribution to journalArticle

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AU - Kerr, Natalie

AU - Nau, Sharon A.

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KW - cerebral dominance

KW - limbic system

KW - nerve net

KW - comorbidity

KW - cerebral cortex

KW - combination drug therapy

KW - oxygen

KW - facial expression

KW - brain mapping

KW - visual pattern recognition

KW - adult

KW - middle aged

KW - amygdala

KW - male

KW - female

KW - emotion processing

KW - functional MRI

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