Enhanced contrast imaging with polyamide 6/Fe(OH)3 nanofibrous scaffolds: A focus on high T1 relaxivity

Congyi Yang, Yifan Jia, Weiwen Yuan, Guoxing Liao, Qianqian Yu*, Zhe Tang, Yuan Ji, Guanghui Liu, Fangrong Tan, Paul D. Topham*, LinGe Wang*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


Nanofibers serve as widely employed tissue engineering scaffolds in diverse biomedical applications. When implanted in vivo, it is crucial for tissue engineering scaffolds to be visualizable, enabling the monitoring of their shape, position, and performance. This capability facilitates the effective assessment of implant deformations, displacements, degradations, and functionalities. However, in many biomedical imaging techniques such as magnetic resonance imaging (MRI), the contrast of tissue engineering scaffolds is often inadequate. MRI is particularly notable for its effectiveness in imaging soft tissues. Previous endeavors to enhance the contrast of tissue engineering scaffolds in MRI have involved the use of negative contrast agents (CAs). Nonetheless, negative CAs can result in artifacts, thus favoring the preference for positive CAs due to their ability to generate clearer boundaries. In this study, we successfully prepared composite polyamide 6 nanofibrous scaffolds with ultrafine dispersion Fe(OH)3 nanoparticles using electrospinning and in-situ growth techniques. The relaxation properties of the magnetic nanofibrous scaffolds confirmed the successful production of scaffolds suitable for positive imaging. In vitro cell seeding experiments demonstrated the efficient proliferation and adhesion of endothelial cells and fibroblasts. In vivo studies further revealed the biocompatibility and functionality of the scaffolds. These findings indicate that the prepared PA6/Fe(OH)3 composite nanofibrous scaffolds can enable straightforward, safe, and efficient in vivo positive contrast MRI monitoring, thereby playing a pivotal role in the integration of diagnosis and treatment within tissue engineering scaffolds.
Original languageEnglish
Article number100259
Number of pages15
Early online date4 Apr 2024
Publication statusE-pub ahead of print - 4 Apr 2024

Bibliographical note

Copyright © 2024, The authors. This is an open access article under the CC BY NC ND license. Published by Elsevier Ltd.


  • Electrospinning
  • Iron-based scaffolds
  • Magnetic nanofibers
  • Magnetic resonance imaging
  • Polyamide 6
  • T positive contrast


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