Enzyme-functionalized thin-cladding long-period fiber grating in transition mode at dispersion turning point for sugar-level and glucose detection

Abdulyezir A. Badmos, Qizhen Sun, Zhongyuan Sun, Junxi Zhang, Zhijun Yan, Petro Lutsyk, Alex Rozhin, Lin Zhang

Research output: Contribution to journalArticle

Abstract

Enzyme-functionalized dual-peak long-period fiber grating (LPFG) inscribed in 80-μm-cladding B/Ge codoped single-mode fiber is presented for sugar-level and specific glucose detection. Before enzyme functionalization, the dual-peak LPFG was employed for refractive index sensing and sugar-level detection and high sensitivities of ∼4298.20  nm/RIU and 4.6696  nm/% were obtained, respectively. Glucose detection probe was attained by surface functionalization of the dual-peak LPFG via covalent binding with aminopropyl triethoxysilane used as a binding site. Optical micrographs confirmed the presence of enzyme. The surface-functionalized dual-peak LPFG was tested with D-(+)-glucose solution of different concentrations. While the peak 2 at the longer wavelength was suitable only to measure lower glucose concentration (0.1 to 1.6  mg/ml) recording a high sensitivity of 12.21±0.19  nm/(mg/ml), the peak 1 at the shorter wavelength was able to measure a wider range of glucose concentrations (0.1 to 3.2  mg/ml) exhibiting a maximum resonance wavelength shift of 7.12±0.12  nm/mg/ml. The enzyme-functionalized dual-peak LPFG has the advantage of direct inscription of highly sensitive grating structures in thin-cladding fibre without etching, and most significantly, its sensitivity improvement of approximately one order of magnitude higher than previously reported LPFG and excessively tilted fibre grating (Ex-TFG) for glucose detection.
Original languageEnglish
Article number027003RR
Number of pages8
JournalJournal of Biomedical Optics
Volume22
Issue number2
DOIs
Publication statusPublished - 6 Feb 2017

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sugars
glucose
Sugars
Glucose
enzymes
Enzymes
gratings
fibers
Fibers
Wavelength
sensitivity
wavelengths
Binding sites
Single mode fibers
Etching
Refractive index
Binding Sites
recording
etching
refractivity

Bibliographical note

© The Authors. Published by SPIE under a Creative Commons Attribution 3.0 Unported License. Distribution or reproduction of this work in whole or in part requires full attribution of the original publication, including its DOI. [DOI: 10.1117/1.JBO.22.2.027003].

Funding: Marie Curie International Incoming Fellowships (FP7-PEOPLE-2013-IIF, 623473 and 913473); and EU FP ‘Horizon-2020’ Marie Skłodowska-Curie Individual Fellowship (FOC4SIP, #654733).

Keywords

  • dual-peak long-period fiber grating
  • D-(+)-glucose
  • covalent binding
  • wavelength shift
  • micrograph
  • enzyme

Cite this

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title = "Enzyme-functionalized thin-cladding long-period fiber grating in transition mode at dispersion turning point for sugar-level and glucose detection",
abstract = "Enzyme-functionalized dual-peak long-period fiber grating (LPFG) inscribed in 80-μm-cladding B/Ge codoped single-mode fiber is presented for sugar-level and specific glucose detection. Before enzyme functionalization, the dual-peak LPFG was employed for refractive index sensing and sugar-level detection and high sensitivities of ∼4298.20  nm/RIU and 4.6696  nm/{\%} were obtained, respectively. Glucose detection probe was attained by surface functionalization of the dual-peak LPFG via covalent binding with aminopropyl triethoxysilane used as a binding site. Optical micrographs confirmed the presence of enzyme. The surface-functionalized dual-peak LPFG was tested with D-(+)-glucose solution of different concentrations. While the peak 2 at the longer wavelength was suitable only to measure lower glucose concentration (0.1 to 1.6  mg/ml) recording a high sensitivity of 12.21±0.19  nm/(mg/ml), the peak 1 at the shorter wavelength was able to measure a wider range of glucose concentrations (0.1 to 3.2  mg/ml) exhibiting a maximum resonance wavelength shift of 7.12±0.12  nm/mg/ml. The enzyme-functionalized dual-peak LPFG has the advantage of direct inscription of highly sensitive grating structures in thin-cladding fibre without etching, and most significantly, its sensitivity improvement of approximately one order of magnitude higher than previously reported LPFG and excessively tilted fibre grating (Ex-TFG) for glucose detection.",
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Enzyme-functionalized thin-cladding long-period fiber grating in transition mode at dispersion turning point for sugar-level and glucose detection. / Badmos, Abdulyezir A.; Sun, Qizhen; Sun, Zhongyuan; Zhang, Junxi; Yan, Zhijun; Lutsyk, Petro; Rozhin, Alex; Zhang, Lin.

In: Journal of Biomedical Optics, Vol. 22, No. 2, 027003RR, 06.02.2017.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Enzyme-functionalized thin-cladding long-period fiber grating in transition mode at dispersion turning point for sugar-level and glucose detection

AU - Badmos, Abdulyezir A.

AU - Sun, Qizhen

AU - Sun, Zhongyuan

AU - Zhang, Junxi

AU - Yan, Zhijun

AU - Lutsyk, Petro

AU - Rozhin, Alex

AU - Zhang, Lin

N1 - © The Authors. Published by SPIE under a Creative Commons Attribution 3.0 Unported License. Distribution or reproduction of this work in whole or in part requires full attribution of the original publication, including its DOI. [DOI: 10.1117/1.JBO.22.2.027003]. Funding: Marie Curie International Incoming Fellowships (FP7-PEOPLE-2013-IIF, 623473 and 913473); and EU FP ‘Horizon-2020’ Marie Skłodowska-Curie Individual Fellowship (FOC4SIP, #654733).

PY - 2017/2/6

Y1 - 2017/2/6

N2 - Enzyme-functionalized dual-peak long-period fiber grating (LPFG) inscribed in 80-μm-cladding B/Ge codoped single-mode fiber is presented for sugar-level and specific glucose detection. Before enzyme functionalization, the dual-peak LPFG was employed for refractive index sensing and sugar-level detection and high sensitivities of ∼4298.20  nm/RIU and 4.6696  nm/% were obtained, respectively. Glucose detection probe was attained by surface functionalization of the dual-peak LPFG via covalent binding with aminopropyl triethoxysilane used as a binding site. Optical micrographs confirmed the presence of enzyme. The surface-functionalized dual-peak LPFG was tested with D-(+)-glucose solution of different concentrations. While the peak 2 at the longer wavelength was suitable only to measure lower glucose concentration (0.1 to 1.6  mg/ml) recording a high sensitivity of 12.21±0.19  nm/(mg/ml), the peak 1 at the shorter wavelength was able to measure a wider range of glucose concentrations (0.1 to 3.2  mg/ml) exhibiting a maximum resonance wavelength shift of 7.12±0.12  nm/mg/ml. The enzyme-functionalized dual-peak LPFG has the advantage of direct inscription of highly sensitive grating structures in thin-cladding fibre without etching, and most significantly, its sensitivity improvement of approximately one order of magnitude higher than previously reported LPFG and excessively tilted fibre grating (Ex-TFG) for glucose detection.

AB - Enzyme-functionalized dual-peak long-period fiber grating (LPFG) inscribed in 80-μm-cladding B/Ge codoped single-mode fiber is presented for sugar-level and specific glucose detection. Before enzyme functionalization, the dual-peak LPFG was employed for refractive index sensing and sugar-level detection and high sensitivities of ∼4298.20  nm/RIU and 4.6696  nm/% were obtained, respectively. Glucose detection probe was attained by surface functionalization of the dual-peak LPFG via covalent binding with aminopropyl triethoxysilane used as a binding site. Optical micrographs confirmed the presence of enzyme. The surface-functionalized dual-peak LPFG was tested with D-(+)-glucose solution of different concentrations. While the peak 2 at the longer wavelength was suitable only to measure lower glucose concentration (0.1 to 1.6  mg/ml) recording a high sensitivity of 12.21±0.19  nm/(mg/ml), the peak 1 at the shorter wavelength was able to measure a wider range of glucose concentrations (0.1 to 3.2  mg/ml) exhibiting a maximum resonance wavelength shift of 7.12±0.12  nm/mg/ml. The enzyme-functionalized dual-peak LPFG has the advantage of direct inscription of highly sensitive grating structures in thin-cladding fibre without etching, and most significantly, its sensitivity improvement of approximately one order of magnitude higher than previously reported LPFG and excessively tilted fibre grating (Ex-TFG) for glucose detection.

KW - dual-peak long-period fiber grating

KW - D-(+)-glucose

KW - covalent binding

KW - wavelength shift

KW - micrograph

KW - enzyme

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