Epidemiological impact of waning immunization on a vaccinated population

Ewa Grela, Michael Stich, Amit K Chattopadhyay

    Research output: Contribution to journalArticlepeer-review


    This is an epidemiological SIRV model based study that is de-
    signed to analyze the impact of vaccination in containing infection spread, in
    a 4-tiered population compartment comprised of susceptible, infected, recov-
    ered and vaccinated agents. While many models assume a lifelong protection
    through vaccination, we focus on the impact of waning immunization due to
    conversion of vaccinated and recovered agents back to susceptible ones. Two
    asymptotic states exist, the \disease-free equilibrium" and the \endemic equi-
    librium" and we express the transitions between these states as function of the
    vaccination and conversion rates and using the basic reproduction number. We
    nd that the vaccination of newborns and adults have dierent consequences
    on controlling an epidemic. Also, a decaying disease protection within the re-
    covered sub-population is not sucient to trigger an epidemic on the linear
    level. We perform simulations for a parameter set modelling a disease with
    waning immunization like pertussis. For a diusively coupled population, a
    transition to the endemic state can proceed via the propagation of a traveling
    infection wave, described successfully within a Fisher-Kolmogorov framework.
    Original languageEnglish
    Article number267
    JournalEuropean Physical Journal B: Condensed Matter and Complex Systems
    Publication statusPublished - 1 Nov 2018

    Bibliographical note

    © The Author(s) 2018. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://doi.org/creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


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