TY - JOUR
T1 - EpiDOCK
T2 - a molecular docking-based tool for MHC class II binding prediction
AU - Atanasova, Mariyana
AU - Patronov, Atanas
AU - Dimitrov, Ivan
AU - Flower, Darren R.
AU - Doytchinova, Irini
PY - 2013/10
Y1 - 2013/10
N2 - Cellular peptide vaccines contain T-cell epitopes. The main prerequisite for a peptide to act as a T-cell epitope is that it binds to a major histocompatibility complex (MHC) protein. Peptide MHC binder identification is an extremely costly experimental challenge since human MHCs, named human leukocyte antigen, are highly polymorphic and polygenic. Here we present EpiDOCK, the first structure-based server for MHC class II binding prediction. EpiDOCK predicts binding to the 23 most frequent human, MHC class II proteins. It identifies 90% of true binders and 76% of true non-binders, with an overall accuracy of 83%. EpiDOCK is freely accessible at http://epidock.ddg-pharmfac. net.
AB - Cellular peptide vaccines contain T-cell epitopes. The main prerequisite for a peptide to act as a T-cell epitope is that it binds to a major histocompatibility complex (MHC) protein. Peptide MHC binder identification is an extremely costly experimental challenge since human MHCs, named human leukocyte antigen, are highly polymorphic and polygenic. Here we present EpiDOCK, the first structure-based server for MHC class II binding prediction. EpiDOCK predicts binding to the 23 most frequent human, MHC class II proteins. It identifies 90% of true binders and 76% of true non-binders, with an overall accuracy of 83%. EpiDOCK is freely accessible at http://epidock.ddg-pharmfac. net.
KW - docking
KW - MHC class II binding prediction
KW - peptide vaccines
KW - quantitative matrices
UR - http://www.scopus.com/inward/record.url?scp=84885003859&partnerID=8YFLogxK
UR - http://peds.oxfordjournals.org/content/26/10/631
U2 - 10.1093/protein/gzt018
DO - 10.1093/protein/gzt018
M3 - Article
C2 - 23661105
AN - SCOPUS:84885003859
SN - 1741-0126
VL - 26
SP - 631
EP - 634
JO - Protein Engineering, Design and Selection
JF - Protein Engineering, Design and Selection
IS - 10
ER -