Exploring the evolution of circular polarized light backscattered from turbid tissue-like disperse medium utilizing generalized Monte Carlo modeling approach with a combined use of Jones and Stokes-Mueller formalisms

Ivan Lopushenko, Oleksii Siery, Alexander Bykov, Igor Meglinski*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

Significance: Phase retardation of circularly polarized light (CPL), backscattered by biological tissue, is used extensively for quantitative evaluation of cervical intraepithelial neoplasia, presence of senile Alzheimer’s plaques, and characterization of biotissues with optical anisotropy. The Stokes polarimetry and Mueller matrix approaches demonstrate high potential in definitive non-invasive cancer diagnosis and tissue characterization. The ultimate understanding of CPL interaction with tissues is essential for advancing medical diagnostics, optical imaging, therapeutic applications, and the development of optical instruments and devices.

Aim: We investigate propagation of CPL within turbid tissue-like scattering medium utilizing a combination of Jones and Stokes–Mueller formalisms in a Monte Carlo (MC) modeling approach. We explore the fundamentals of CPL memory effect and depolarization formation.

Approach: The generalized MC computational approach developed for polarization tracking within turbid tissue-like scattering medium is based on the iterative solution of the Bethe–Salpeter equation. The approach handles helicity response of CPL scattered in turbid medium and provides explicit expressions for assessment of its polarization state.

Results: Evolution of CPL backscattered by tissue-like medium at different conditions of observation in terms of source–detector configuration is assessed quantitatively. The depolarization of light is presented in terms of the coherence matrix and Stokes–Mueller formalism. The obtained results reveal the origins of the helicity flip of CPL depending on the source–detector configuration and the properties of the medium and are in a good agreement with the experiment.

Conclusions: By integrating Jones and Stokes–Mueller formalisms, the combined MC approach allows for a more complete representation of polarization effects in complex optical systems. The developed model is suitable to imitate propagation of the light beams of different shape and profile, including Gaussian, Bessel, Hermite–Gaussian, and Laguerre–Gaussian beams, within tissue-like medium. Diverse configuration of the experimental conditions, coherent properties of light, and peculiarities of polarization can be also taken into account.
Original languageEnglish
Article number052913
Number of pages19
JournalJournal of Biomedical Optics
Volume29
Issue number5
Early online date21 Nov 2023
DOIs
Publication statusE-pub ahead of print - 21 Nov 2023

Bibliographical note

Copyright © The Authors. Published by SPIE under a Creative Commons Attribution 4.0 International License. Distribution or reproduction of this work in whole or in part requires full attribution of the original publication, including its DOI. [DOI: 10.1117/1.JBO.29.5.052913].

Funding & Acknowledgments: The authors acknowledge the support from ATTRACT II META-HiLight project funded by the European Union’s Horizon 2020 research and innovative programme under Grant Agreement No. 101004462, the Academy of Finland (Grant Project 325097), the Leverhulme Trust and The Royal Society (Ref. No.: APX111232 APEX Awards 2021).

Keywords

  • Circularly polarized light
  • Monte Carlo
  • Stokes vector
  • Jones-Mueller approach
  • polarimetry
  • turbid tissue-like scattering medium
  • Optical Devices
  • Anisotropy
  • Scattering, Radiation
  • Spectrum Analysis
  • Monte Carlo Method

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