Factors determining the size frequency distribution of β-amyloid (Aβ) deposits in Alzheimer's disease

Richard A. Armstrong, D. Myers, C.U.M. Smith

Research output: Contribution to journalArticle

Abstract

The size frequency distributions of discrete β-amyloid (Aβ) deposits were studied in single sections of the temporal lobe from patients with Alzheimer's disease. The size distributions were unimodal and positively skewed. In 18/25 (72%) tissues examined, a log normal distribution was a good fit to the data. This suggests that the abundances of deposit sizes are distributed randomly on a log scale about a mean value. Three hypotheses were proposed to account for the data: (1) sectioning in a single plane, (2) growth and disappearance of Aβ deposits, and (3) the origin of Aβ deposits from clusters of neuronal cell bodies. Size distributions obtained by serial reconstruction through the tissue were similar to those observed in single sections, which would not support the first hypothesis. The log normal distribution of Aβ deposit size suggests a model in which the rate of growth of a deposit is proportional to its volume. However, mean deposit size and the ratio of large to small deposits were not positively correlated with patient age or disease duration. The frequency distribution of Aβ deposits which were closely associated with 0, 1, 2, 3, or more neuronal cell bodies deviated significantly from a log normal distribution, which would not support the neuronal origin hypothesis. On the basis of the present data, growth and resolution of Aβ deposits would appear to be the most likely explanation for the log normal size distributions.

Original languageEnglish
Pages (from-to)574-579
Number of pages6
JournalExperimental Neurology
Volume145
Issue number2
DOIs
Publication statusPublished - Jun 1997

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Normal Distribution
Amyloid Plaques
Alzheimer Disease
Growth
Temporal Lobe
Cell Body

Keywords

  • size frequency distribution
  • discrete beta-amyloid deposit
  • temporal lobe
  • Alzheimer's disease

Cite this

Armstrong, Richard A. ; Myers, D. ; Smith, C.U.M. / Factors determining the size frequency distribution of β-amyloid (Aβ) deposits in Alzheimer's disease. In: Experimental Neurology . 1997 ; Vol. 145, No. 2. pp. 574-579.
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Factors determining the size frequency distribution of β-amyloid (Aβ) deposits in Alzheimer's disease. / Armstrong, Richard A.; Myers, D.; Smith, C.U.M.

In: Experimental Neurology , Vol. 145, No. 2, 06.1997, p. 574-579.

Research output: Contribution to journalArticle

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