@inproceedings{75f3176804694287a3f82c395c839a89,
title = "Fibre-optic probe for fluorescence diagnostics with blood influence compensation",
abstract = "To minimise the influence of blood content on the fluorescence measurements in vivo, a fibre optical probe combining fluorescence and diffuse reflectance measurements was developed. For the inverse solution of the blood content recovery, a set of neural networks trained by the Monte Carlo generated learning set was used. An approach of fluorescence measurements triggered by simultaneous real-time measurements of blood content in living tissue during moderate changes in contact pressure of the optic probe is proposed. The method allows one to decrease the necessary pressure on the probe as well as increase the repeatability of the measurements. The developed approach was verified in a series of experiments on volunteers with fluorescence excitation at 365 nm and 450 nm. The proposed technology is of particular interest in the development of new fluorescence-based optical biopsy systems.",
keywords = "attenuation correction, blood content, diffuse reflectance, fluorescence measurements in vivo, Monte Carlo simulation, neural network, probe pressure",
author = "Evgeny Zherebtsov and Viktor Dremin and Elena Zharkikh and Angelina Zherebtsova and Ilya Rafailov and Andrey Dunaev and Natalia Bazieva and Edik Rafailov",
note = "Copyright {\textcopyright} 2018 Society of Photo-Optical Instrumentation Engineers (SPIE). One print or electronic copy may be made for personal use only. Systematic reproduction and distribution, duplication of any material in this paper for a fee or for commercial purposes, or modification of the content of the paper are prohibited. ; Dynamics and Fluctuations in Biomedical Photonics XV 2018 ; Conference date: 28-01-2018 Through 29-01-2018",
year = "2018",
month = feb,
day = "26",
doi = "10.1117/12.2290431",
language = "English",
series = "Progress in Biomedical Optics and Imaging - Proceedings of SPIE",
pages = "58",
editor = "Tuchin, {Valery V.} and Wang, {Ruikang K.} and Leahy, {Martin J.} and Tuchin, {Valery V.} and Larin, {Kirill V.}",
booktitle = "Dynamics and Fluctuations in Biomedical Photonics XV",
}