Gaps and barriers in the control of blood glucose in people with type 2 diabetes

Lawrence Blonde*, Pablo Aschner, Clifford Bailey, Linong Ji, Lawrence A. Leiter, Stephan Matthaei,

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review


Background: Glycaemic control is suboptimal in a large proportion of people with type 2 diabetes who are consequently at an increased and avoidable risk of potentially severe complications. We sought to explore attitudes and practices among healthcare professionals that may contribute to suboptimal glycaemic control through a review of recent relevant publications in the scientific literature. Methods: An electronic search of the PubMed database was performed to identify relevant publications from January 2011 to July 2015. The electronic search was complemented by a manual search of abstracts from key diabetes conferences in 2014/2015 available online. Results: Recently published data indicate that glycaemic control is suboptimal in a substantial proportion (typically 40%-60%) of people with diabetes. This is the case across geographic regions and in both low- and higher-income countries. Therapeutic inertia appears to be an important contributor to poor glycaemic control in up to half of people with type 2 diabetes. In particular, prescribers are often willing to tolerate extended periods of 'mild' hyperglycaemia as well as having low expectations for their patients. There are often delays of 3 years or longer in initiating or intensifying glucose-lowering therapy when needed. Conclusion: Many people with type 2 diabetes are failed by current management, with approximately half not achieving or maintaining appropriate target blood glucose levels, leaving these patients at increased and avoidable risk of serious complications. Review criteria: The methodology of this review article is detailed in the 'Methods' section.

Original languageEnglish
Pages (from-to)172-183
Number of pages12
JournalDiabetes and Vascular Disease Research
Issue number3
Early online date1 Feb 2017
Publication statusPublished - 1 May 2017

Bibliographical note

© The Author(s) 2017. This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License ( which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access page (


  • clinical inertia
  • diabetes mellitus
  • glycaemic control
  • review
  • surveys
  • type 2


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