Generating iPSCs: translating cell reprogramming science into scalable and robust biomanufacturing strategies

Marli Silva; Laurence Daheron; Hannah Hurley; Kim Bure; Richard Barker; Andrew J Carr; David Williams; Hae-Won Kim; Anna French; Pete J Coffey; Justin J Cooper-White; Brock Reeve; Mahendra Rao; Evan Y Snyder; Kelvin S Ng; Benjamin E Mead; James A Smith; Jeffrey M Karp; David A Brindley; Ivan Wall

doi:10.1016/j.stem.2014.12.013

Generating iPSCs: translating cell reprogramming science into scalable and robust biomanufacturing strategies

Marli Silva, Laurence Daheron, Hannah Hurley, Kim Bure, Richard Barker, Andrew J Carr, David Williams, Hae-Won Kim, Anna French, Pete J Coffey, Justin J Cooper-White, Brock Reeve, Mahendra Rao, Evan Y Snyder, Kelvin S Ng, Benjamin E Mead, James A Smith, Jeffrey M Karp, David A Brindley, Ivan Wall

Research output: Contribution to journal › Article › peer-review

Abstract

Induced pluripotent stem cells (iPSCs) have the potential to transform drug discovery and healthcare in the 21(st) century. However, successful commercialization will require standardized manufacturing platforms. Here we highlight the need to define standardized practices for iPSC generation and processing and discuss current challenges to the robust manufacture of iPSC products.

Original language	English
Pages (from-to)	13-17
Number of pages	5
Journal	Cell stem cell
Volume	16
Issue number	1
DOIs	https://doi.org/10.1016/j.stem.2014.12.013
Publication status	Published - 8 Jan 2015

Bibliographical note

Keywords

Animals
Cell Culture Techniques/methods
Cellular Reprogramming
Humans
Induced Pluripotent Stem Cells/cytology
Reproducibility of Results
Stem Cell Transplantation

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10.1016/j.stem.2014.12.013

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Silva, M., Daheron, L., Hurley, H., Bure, K., Barker, R., Carr, A. J., Williams, D., Kim, H.-W., French, A., Coffey, P. J., Cooper-White, J. J., Reeve, B., Rao, M., Snyder, E. Y., Ng, K. S., Mead, B. E., Smith, J. A., Karp, J. M., Brindley, D. A., & Wall, I. (2015). Generating iPSCs: translating cell reprogramming science into scalable and robust biomanufacturing strategies. Cell stem cell, 16(1), 13-17. https://doi.org/10.1016/j.stem.2014.12.013

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abstract = "Induced pluripotent stem cells (iPSCs) have the potential to transform drug discovery and healthcare in the 21(st) century. However, successful commercialization will require standardized manufacturing platforms. Here we highlight the need to define standardized practices for iPSC generation and processing and discuss current challenges to the robust manufacture of iPSC products. ",

keywords = "Animals, Cell Culture Techniques/methods, Cellular Reprogramming, Humans, Induced Pluripotent Stem Cells/cytology, Reproducibility of Results, Stem Cell Transplantation",

author = "Marli Silva and Laurence Daheron and Hannah Hurley and Kim Bure and Richard Barker and Carr, {Andrew J} and David Williams and Hae-Won Kim and Anna French and Coffey, {Pete J} and Cooper-White, {Justin J} and Brock Reeve and Mahendra Rao and Snyder, {Evan Y} and Ng, {Kelvin S} and Mead, {Benjamin E} and Smith, {James A} and Karp, {Jeffrey M} and Brindley, {David A} and Ivan Wall",

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doi = "10.1016/j.stem.2014.12.013",

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Silva, M, Daheron, L, Hurley, H, Bure, K, Barker, R, Carr, AJ, Williams, D, Kim, H-W, French, A, Coffey, PJ, Cooper-White, JJ, Reeve, B, Rao, M, Snyder, EY, Ng, KS, Mead, BE, Smith, JA, Karp, JM, Brindley, DA & Wall, I 2015, 'Generating iPSCs: translating cell reprogramming science into scalable and robust biomanufacturing strategies', Cell stem cell, vol. 16, no. 1, pp. 13-17. https://doi.org/10.1016/j.stem.2014.12.013

TY - JOUR

T1 - Generating iPSCs

T2 - translating cell reprogramming science into scalable and robust biomanufacturing strategies

AU - Silva, Marli

AU - Daheron, Laurence

AU - Hurley, Hannah

AU - Bure, Kim

AU - Barker, Richard

AU - Carr, Andrew J

AU - Williams, David

AU - Kim, Hae-Won

AU - French, Anna

AU - Coffey, Pete J

AU - Cooper-White, Justin J

AU - Reeve, Brock

AU - Rao, Mahendra

AU - Snyder, Evan Y

AU - Ng, Kelvin S

AU - Mead, Benjamin E

AU - Smith, James A

AU - Karp, Jeffrey M

AU - Brindley, David A

AU - Wall, Ivan

PY - 2015/1/8

Y1 - 2015/1/8

N2 - Induced pluripotent stem cells (iPSCs) have the potential to transform drug discovery and healthcare in the 21(st) century. However, successful commercialization will require standardized manufacturing platforms. Here we highlight the need to define standardized practices for iPSC generation and processing and discuss current challenges to the robust manufacture of iPSC products.

AB - Induced pluripotent stem cells (iPSCs) have the potential to transform drug discovery and healthcare in the 21(st) century. However, successful commercialization will require standardized manufacturing platforms. Here we highlight the need to define standardized practices for iPSC generation and processing and discuss current challenges to the robust manufacture of iPSC products.

KW - Animals

KW - Cell Culture Techniques/methods

KW - Cellular Reprogramming

KW - Humans

KW - Induced Pluripotent Stem Cells/cytology

KW - Reproducibility of Results

KW - Stem Cell Transplantation

UR - https://www.sciencedirect.com/science/article/pii/S1934590914005712?via%3Dihub

U2 - 10.1016/j.stem.2014.12.013

DO - 10.1016/j.stem.2014.12.013

M3 - Article

C2 - 25575079

SN - 1875-9777

VL - 16

SP - 13

EP - 17

JO - Cell stem cell

JF - Cell stem cell

IS - 1

ER -

Generating iPSCs: translating cell reprogramming science into scalable and robust biomanufacturing strategies

Abstract

Bibliographical note

Keywords

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