Abstract
Vaccine design is highly suited to the application of in silico techniques, for both the discovery and development of new and existing vaccines. Here, we discuss computational contributions to epitope mapping and reverse vaccinology, two techniques central to the new discipline of immunomics. Also discussed are methods to improve the efficiency of vaccination, such as codon optimization and adjuvant discovery in addition to the identification of allergenic proteins. We also review current software developed to facilitate vaccine design.
| Original language | English |
|---|---|
| Pages (from-to) | 389-395 |
| Number of pages | 7 |
| Journal | Drug Discovery Today |
| Volume | 12 |
| Issue number | 9-10 |
| Early online date | 6 Apr 2007 |
| DOIs | |
| Publication status | Published - May 2007 |
Keywords
- vaccine design
- bioinformatics
Fingerprint Dive into the research topics of 'Harnessing bioinformatics to discover new vaccines'. Together they form a unique fingerprint.
Cite this
Davies, M. N., & Flower, D. R. (2007). Harnessing bioinformatics to discover new vaccines. Drug Discovery Today, 12(9-10), 389-395. https://doi.org/10.1016/j.drudis.2007.03.010