Harnessing bioinformatics to discover new vaccines

Matthew N. Davies; Darren R. Flower

doi:10.1016/j.drudis.2007.03.010

Harnessing bioinformatics to discover new vaccines

Matthew N. Davies, Darren R. Flower

Research output: Contribution to journal › Article › peer-review

Abstract

Vaccine design is highly suited to the application of in silico techniques, for both the discovery and development of new and existing vaccines. Here, we discuss computational contributions to epitope mapping and reverse vaccinology, two techniques central to the new discipline of immunomics. Also discussed are methods to improve the efficiency of vaccination, such as codon optimization and adjuvant discovery in addition to the identification of allergenic proteins. We also review current software developed to facilitate vaccine design.

Original language	English
Pages (from-to)	389-395
Number of pages	7
Journal	Drug Discovery Today
Volume	12
Issue number	9-10
Early online date	6 Apr 2007
DOIs	https://doi.org/10.1016/j.drudis.2007.03.010
Publication status	Published - May 2007

Keywords

vaccine design
bioinformatics

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10.1016/j.drudis.2007.03.010

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title = "Harnessing bioinformatics to discover new vaccines",

abstract = "Vaccine design is highly suited to the application of in silico techniques, for both the discovery and development of new and existing vaccines. Here, we discuss computational contributions to epitope mapping and reverse vaccinology, two techniques central to the new discipline of immunomics. Also discussed are methods to improve the efficiency of vaccination, such as codon optimization and adjuvant discovery in addition to the identification of allergenic proteins. We also review current software developed to facilitate vaccine design.",

keywords = "vaccine design, bioinformatics",

author = "Davies, {Matthew N.} and Flower, {Darren R.}",

year = "2007",

month = may,

doi = "10.1016/j.drudis.2007.03.010",

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AU - Flower, Darren R.

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AB - Vaccine design is highly suited to the application of in silico techniques, for both the discovery and development of new and existing vaccines. Here, we discuss computational contributions to epitope mapping and reverse vaccinology, two techniques central to the new discipline of immunomics. Also discussed are methods to improve the efficiency of vaccination, such as codon optimization and adjuvant discovery in addition to the identification of allergenic proteins. We also review current software developed to facilitate vaccine design.

KW - vaccine design

KW - bioinformatics

U2 - 10.1016/j.drudis.2007.03.010

DO - 10.1016/j.drudis.2007.03.010

M3 - Article

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VL - 12

SP - 389

EP - 395

JO - Drug Discovery Today

JF - Drug Discovery Today

SN - 1359-6446

IS - 9-10

ER -

Harnessing bioinformatics to discover new vaccines

Abstract

Keywords

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