Harnessing bioinformatics to discover new vaccines

Matthew N. Davies, Darren R. Flower

Research output: Contribution to journalArticle

Abstract

Vaccine design is highly suited to the application of in silico techniques, for both the discovery and development of new and existing vaccines. Here, we discuss computational contributions to epitope mapping and reverse vaccinology, two techniques central to the new discipline of immunomics. Also discussed are methods to improve the efficiency of vaccination, such as codon optimization and adjuvant discovery in addition to the identification of allergenic proteins. We also review current software developed to facilitate vaccine design.
Original languageEnglish
Pages (from-to)389-395
Number of pages7
JournalDrug Discovery Today
Volume12
Issue number9-10
Early online date6 Apr 2007
DOIs
Publication statusPublished - May 2007

Fingerprint

Computational Biology
Vaccines
Epitope Mapping
Codon
Computer Simulation
Vaccination
Software
Proteins

Keywords

  • vaccine design
  • bioinformatics

Cite this

Davies, Matthew N. ; Flower, Darren R. / Harnessing bioinformatics to discover new vaccines. In: Drug Discovery Today. 2007 ; Vol. 12, No. 9-10. pp. 389-395.
@article{4862e02f65e646de9c02aabdbcb9a41e,
title = "Harnessing bioinformatics to discover new vaccines",
abstract = "Vaccine design is highly suited to the application of in silico techniques, for both the discovery and development of new and existing vaccines. Here, we discuss computational contributions to epitope mapping and reverse vaccinology, two techniques central to the new discipline of immunomics. Also discussed are methods to improve the efficiency of vaccination, such as codon optimization and adjuvant discovery in addition to the identification of allergenic proteins. We also review current software developed to facilitate vaccine design.",
keywords = "vaccine design, bioinformatics",
author = "Davies, {Matthew N.} and Flower, {Darren R.}",
year = "2007",
month = "5",
doi = "10.1016/j.drudis.2007.03.010",
language = "English",
volume = "12",
pages = "389--395",
journal = "Drug Discovery Today",
issn = "1359-6446",
publisher = "Elsevier",
number = "9-10",

}

Harnessing bioinformatics to discover new vaccines. / Davies, Matthew N.; Flower, Darren R.

In: Drug Discovery Today, Vol. 12, No. 9-10, 05.2007, p. 389-395.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Harnessing bioinformatics to discover new vaccines

AU - Davies, Matthew N.

AU - Flower, Darren R.

PY - 2007/5

Y1 - 2007/5

N2 - Vaccine design is highly suited to the application of in silico techniques, for both the discovery and development of new and existing vaccines. Here, we discuss computational contributions to epitope mapping and reverse vaccinology, two techniques central to the new discipline of immunomics. Also discussed are methods to improve the efficiency of vaccination, such as codon optimization and adjuvant discovery in addition to the identification of allergenic proteins. We also review current software developed to facilitate vaccine design.

AB - Vaccine design is highly suited to the application of in silico techniques, for both the discovery and development of new and existing vaccines. Here, we discuss computational contributions to epitope mapping and reverse vaccinology, two techniques central to the new discipline of immunomics. Also discussed are methods to improve the efficiency of vaccination, such as codon optimization and adjuvant discovery in addition to the identification of allergenic proteins. We also review current software developed to facilitate vaccine design.

KW - vaccine design

KW - bioinformatics

U2 - 10.1016/j.drudis.2007.03.010

DO - 10.1016/j.drudis.2007.03.010

M3 - Article

C2 - 17467575

VL - 12

SP - 389

EP - 395

JO - Drug Discovery Today

JF - Drug Discovery Today

SN - 1359-6446

IS - 9-10

ER -