Harnessing bioinformatics to discover new vaccines

Matthew N. Davies, Darren R. Flower

Research output: Contribution to journalArticlepeer-review


Vaccine design is highly suited to the application of in silico techniques, for both the discovery and development of new and existing vaccines. Here, we discuss computational contributions to epitope mapping and reverse vaccinology, two techniques central to the new discipline of immunomics. Also discussed are methods to improve the efficiency of vaccination, such as codon optimization and adjuvant discovery in addition to the identification of allergenic proteins. We also review current software developed to facilitate vaccine design.
Original languageEnglish
Pages (from-to)389-395
Number of pages7
JournalDrug Discovery Today
Issue number9-10
Early online date6 Apr 2007
Publication statusPublished - May 2007


  • vaccine design
  • bioinformatics


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