Abstract
| Original language | English |
|---|---|
| Pages (from-to) | 389-395 |
| Number of pages | 7 |
| Journal | Drug Discovery Today |
| Volume | 12 |
| Issue number | 9-10 |
| Early online date | 6 Apr 2007 |
| DOIs | |
| Publication status | Published - May 2007 |
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Keywords
- vaccine design
- bioinformatics
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Harnessing bioinformatics to discover new vaccines. / Davies, Matthew N.; Flower, Darren R.
In: Drug Discovery Today, Vol. 12, No. 9-10, 05.2007, p. 389-395.Research output: Contribution to journal › Article
TY - JOUR
T1 - Harnessing bioinformatics to discover new vaccines
AU - Davies, Matthew N.
AU - Flower, Darren R.
PY - 2007/5
Y1 - 2007/5
N2 - Vaccine design is highly suited to the application of in silico techniques, for both the discovery and development of new and existing vaccines. Here, we discuss computational contributions to epitope mapping and reverse vaccinology, two techniques central to the new discipline of immunomics. Also discussed are methods to improve the efficiency of vaccination, such as codon optimization and adjuvant discovery in addition to the identification of allergenic proteins. We also review current software developed to facilitate vaccine design.
AB - Vaccine design is highly suited to the application of in silico techniques, for both the discovery and development of new and existing vaccines. Here, we discuss computational contributions to epitope mapping and reverse vaccinology, two techniques central to the new discipline of immunomics. Also discussed are methods to improve the efficiency of vaccination, such as codon optimization and adjuvant discovery in addition to the identification of allergenic proteins. We also review current software developed to facilitate vaccine design.
KW - vaccine design
KW - bioinformatics
U2 - 10.1016/j.drudis.2007.03.010
DO - 10.1016/j.drudis.2007.03.010
M3 - Article
C2 - 17467575
VL - 12
SP - 389
EP - 395
JO - Drug Discovery Today
JF - Drug Discovery Today
SN - 1359-6446
IS - 9-10
ER -