High-pressure phase behaviour of nicotine / carbon dioxide system

Alejandro Ruiz-Rodríguez, Vesna Najdanovic-Visak, Manuel Nunes da Ponte

Research output: Contribution to conferenceAbstract

Abstract

Tobacco products are composed of a great variety of constituents. Nicotine, 1-methyl-2(3-pyridyl) pyrrolidine, is a highly toxic major alkaloid found in tobacco plants and plays an important etiological role in the development of human carcinogenesis. Nicotine is also accused of the addictive potential of smoking, being classified by the Drug Abuse Advisory Committee as an addictive substance. Carbon dioxide has been extensively used for the removal of nicotine from tobacco leaves in the production of new cigarettes with reduced nicotine content. Although detailed knowledge of phase behaviour is most important for the design of any separation process, solubility of nicotine in sub/supercritical CO2 seems to have been scarcely studied. Reported measurements are restricted to the temperatures of 313 and 343 K, and covering a range of pressures of 0.9 – 8 MPa and 0.9 – 16 MPa, respectively.
In this work we present a phase behaviour study of the CO2-nicotine binary system at 313.1 K, in a pressure range of 6 to 9 MPa. The phase equilibrium measurements were performed using an apparatus that employs a high-pressure sapphire cell and allows sampling of both vapour and liquid phases. From the experimental work, it could be concluded that, according to the Scott and Van Konynenburg classification of fluid phase equilibria, the system nicotine + CO2 most likely shows type-V fluid phase behaviour. The characteristic of this type of phase behaviour is a three-phase (VLL) equilibrium, with a discontinuous critical curve. As expected, the mutual miscibility increases with increasing pressure and the mixture will be homogeneous above the upper critical pressures. These data may help in further studies on sub/supercritical CO2 extraction of nicotine from nicotine-containing products.
Original languageEnglish
Publication statusPublished - 2008

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Phase behavior
Nicotine
Carbon Dioxide
Phase equilibria
Tobacco
Tobacco Products
Solubility
Fluids
Aluminum Oxide
Poisons
Alkaloids
Vapors
Sampling
Liquids
Pharmaceutical Preparations

Cite this

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title = "High-pressure phase behaviour of nicotine / carbon dioxide system",
abstract = "Tobacco products are composed of a great variety of constituents. Nicotine, 1-methyl-2(3-pyridyl) pyrrolidine, is a highly toxic major alkaloid found in tobacco plants and plays an important etiological role in the development of human carcinogenesis. Nicotine is also accused of the addictive potential of smoking, being classified by the Drug Abuse Advisory Committee as an addictive substance. Carbon dioxide has been extensively used for the removal of nicotine from tobacco leaves in the production of new cigarettes with reduced nicotine content. Although detailed knowledge of phase behaviour is most important for the design of any separation process, solubility of nicotine in sub/supercritical CO2 seems to have been scarcely studied. Reported measurements are restricted to the temperatures of 313 and 343 K, and covering a range of pressures of 0.9 – 8 MPa and 0.9 – 16 MPa, respectively.In this work we present a phase behaviour study of the CO2-nicotine binary system at 313.1 K, in a pressure range of 6 to 9 MPa. The phase equilibrium measurements were performed using an apparatus that employs a high-pressure sapphire cell and allows sampling of both vapour and liquid phases. From the experimental work, it could be concluded that, according to the Scott and Van Konynenburg classification of fluid phase equilibria, the system nicotine + CO2 most likely shows type-V fluid phase behaviour. The characteristic of this type of phase behaviour is a three-phase (VLL) equilibrium, with a discontinuous critical curve. As expected, the mutual miscibility increases with increasing pressure and the mixture will be homogeneous above the upper critical pressures. These data may help in further studies on sub/supercritical CO2 extraction of nicotine from nicotine-containing products.",
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High-pressure phase behaviour of nicotine / carbon dioxide system. / Ruiz-Rodríguez, Alejandro; Najdanovic-Visak, Vesna; Ponte, Manuel Nunes da.

2008.

Research output: Contribution to conferenceAbstract

TY - CONF

T1 - High-pressure phase behaviour of nicotine / carbon dioxide system

AU - Ruiz-Rodríguez, Alejandro

AU - Najdanovic-Visak, Vesna

AU - Ponte, Manuel Nunes da

PY - 2008

Y1 - 2008

N2 - Tobacco products are composed of a great variety of constituents. Nicotine, 1-methyl-2(3-pyridyl) pyrrolidine, is a highly toxic major alkaloid found in tobacco plants and plays an important etiological role in the development of human carcinogenesis. Nicotine is also accused of the addictive potential of smoking, being classified by the Drug Abuse Advisory Committee as an addictive substance. Carbon dioxide has been extensively used for the removal of nicotine from tobacco leaves in the production of new cigarettes with reduced nicotine content. Although detailed knowledge of phase behaviour is most important for the design of any separation process, solubility of nicotine in sub/supercritical CO2 seems to have been scarcely studied. Reported measurements are restricted to the temperatures of 313 and 343 K, and covering a range of pressures of 0.9 – 8 MPa and 0.9 – 16 MPa, respectively.In this work we present a phase behaviour study of the CO2-nicotine binary system at 313.1 K, in a pressure range of 6 to 9 MPa. The phase equilibrium measurements were performed using an apparatus that employs a high-pressure sapphire cell and allows sampling of both vapour and liquid phases. From the experimental work, it could be concluded that, according to the Scott and Van Konynenburg classification of fluid phase equilibria, the system nicotine + CO2 most likely shows type-V fluid phase behaviour. The characteristic of this type of phase behaviour is a three-phase (VLL) equilibrium, with a discontinuous critical curve. As expected, the mutual miscibility increases with increasing pressure and the mixture will be homogeneous above the upper critical pressures. These data may help in further studies on sub/supercritical CO2 extraction of nicotine from nicotine-containing products.

AB - Tobacco products are composed of a great variety of constituents. Nicotine, 1-methyl-2(3-pyridyl) pyrrolidine, is a highly toxic major alkaloid found in tobacco plants and plays an important etiological role in the development of human carcinogenesis. Nicotine is also accused of the addictive potential of smoking, being classified by the Drug Abuse Advisory Committee as an addictive substance. Carbon dioxide has been extensively used for the removal of nicotine from tobacco leaves in the production of new cigarettes with reduced nicotine content. Although detailed knowledge of phase behaviour is most important for the design of any separation process, solubility of nicotine in sub/supercritical CO2 seems to have been scarcely studied. Reported measurements are restricted to the temperatures of 313 and 343 K, and covering a range of pressures of 0.9 – 8 MPa and 0.9 – 16 MPa, respectively.In this work we present a phase behaviour study of the CO2-nicotine binary system at 313.1 K, in a pressure range of 6 to 9 MPa. The phase equilibrium measurements were performed using an apparatus that employs a high-pressure sapphire cell and allows sampling of both vapour and liquid phases. From the experimental work, it could be concluded that, according to the Scott and Van Konynenburg classification of fluid phase equilibria, the system nicotine + CO2 most likely shows type-V fluid phase behaviour. The characteristic of this type of phase behaviour is a three-phase (VLL) equilibrium, with a discontinuous critical curve. As expected, the mutual miscibility increases with increasing pressure and the mixture will be homogeneous above the upper critical pressures. These data may help in further studies on sub/supercritical CO2 extraction of nicotine from nicotine-containing products.

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M3 - Abstract

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