Improved thyroid hypoechogenicity following bariatric-induced weight loss in euthyroid adults with severe Obesity-a pilot study

Ioannis Kyrou, Olu Adesanya, Nicholas Hedley, Sarah Wayte, Dimitris Grammatopoulos, Claire L. Thomas, Andrew Weedall, Subash Sivaraman, Lavanya Pelluri, Thomas M. Barber, Vinod Menon, Harpal S. Randeva, Miroslav Tedla, Martin O. Weickert*

*Corresponding author for this work

Research output: Contribution to journalArticle

Abstract

Background: Obesity may affect both biochemical thyroid function tests; and thyroid morphology, as assessed using ultrasound scans (US). The aim of the present pilot study was to explore whether weight loss achieved by bariatric surgery alters thyroid US morphology including gray-scale measurements; and/or function in euthyroid adults with severe obesity. Methods: Euthyroid adults (> 18 years) with body mass index (BMI) ≥40 kg/m2 and negative thyroid peroxidase antibodies were assessed at baseline (pre-surgery) and after achieving at least 5% weight loss of their baseline body weight following bariatric surgery. Anthropometric assessments, biochemical/hormonal measurements (TSH, free-T4, free-T3, reverse-T3, and leptin) and thyroid US with gray-scale histogram analysis were performed at the baseline and post-surgery follow-up. Results: Ten Caucasian, euthyroid patients (women/men: 8/2; age: 48.6 ± 3.1 years; BMI: 51.4 ± 1.8 kg/m2) successfully completed this study with significantly decreased body weight (> 5% weight loss), waist circumference and serum leptin levels post-surgery (mean post-surgery follow-up duration: 16.5 ± 2.5 months). In parallel to the observed bariatric-induced weight loss, thyroid US echogenicity increased by 25% (p = 0.03), without significant changes in thyroid volume. No significant changes in thyroid function tests were detected. No significant correlations were observed between the increase in thyroid echogenicity and the decreases in anthropometric parameters and circulating leptin. Conclusion: Our results indicate that in euthyroid adults with severe obesity, marked weight loss achieved by bariatric surgery is associated with a parallel significant increase in the thyroid US echogenicity, suggesting that morphological changes of the thyroid in obesity are reversible with weight loss.

Original languageEnglish
Article number488
JournalFrontiers in Endocrinology
Volume9
DOIs
Publication statusPublished - 24 Aug 2018

Fingerprint

Bariatrics
Morbid Obesity
Weight Loss
Thyroid Gland
Bariatric Surgery
Leptin
Thyroid Function Tests
Body Mass Index
Obesity
Body Weight
Iodide Peroxidase
Waist Circumference
Antibodies

Keywords

  • Bariatric surgery
  • Gray-scale
  • Obesity
  • Thyroid echogenicity
  • TSH
  • Ultrasound

Cite this

Kyrou, Ioannis ; Adesanya, Olu ; Hedley, Nicholas ; Wayte, Sarah ; Grammatopoulos, Dimitris ; Thomas, Claire L. ; Weedall, Andrew ; Sivaraman, Subash ; Pelluri, Lavanya ; Barber, Thomas M. ; Menon, Vinod ; Randeva, Harpal S. ; Tedla, Miroslav ; Weickert, Martin O. / Improved thyroid hypoechogenicity following bariatric-induced weight loss in euthyroid adults with severe Obesity-a pilot study. In: Frontiers in Endocrinology. 2018 ; Vol. 9.
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title = "Improved thyroid hypoechogenicity following bariatric-induced weight loss in euthyroid adults with severe Obesity-a pilot study",
abstract = "Background: Obesity may affect both biochemical thyroid function tests; and thyroid morphology, as assessed using ultrasound scans (US). The aim of the present pilot study was to explore whether weight loss achieved by bariatric surgery alters thyroid US morphology including gray-scale measurements; and/or function in euthyroid adults with severe obesity. Methods: Euthyroid adults (> 18 years) with body mass index (BMI) ≥40 kg/m2 and negative thyroid peroxidase antibodies were assessed at baseline (pre-surgery) and after achieving at least 5{\%} weight loss of their baseline body weight following bariatric surgery. Anthropometric assessments, biochemical/hormonal measurements (TSH, free-T4, free-T3, reverse-T3, and leptin) and thyroid US with gray-scale histogram analysis were performed at the baseline and post-surgery follow-up. Results: Ten Caucasian, euthyroid patients (women/men: 8/2; age: 48.6 ± 3.1 years; BMI: 51.4 ± 1.8 kg/m2) successfully completed this study with significantly decreased body weight (> 5{\%} weight loss), waist circumference and serum leptin levels post-surgery (mean post-surgery follow-up duration: 16.5 ± 2.5 months). In parallel to the observed bariatric-induced weight loss, thyroid US echogenicity increased by 25{\%} (p = 0.03), without significant changes in thyroid volume. No significant changes in thyroid function tests were detected. No significant correlations were observed between the increase in thyroid echogenicity and the decreases in anthropometric parameters and circulating leptin. Conclusion: Our results indicate that in euthyroid adults with severe obesity, marked weight loss achieved by bariatric surgery is associated with a parallel significant increase in the thyroid US echogenicity, suggesting that morphological changes of the thyroid in obesity are reversible with weight loss.",
keywords = "Bariatric surgery, Gray-scale, Obesity, Thyroid echogenicity, TSH, Ultrasound",
author = "Ioannis Kyrou and Olu Adesanya and Nicholas Hedley and Sarah Wayte and Dimitris Grammatopoulos and Thomas, {Claire L.} and Andrew Weedall and Subash Sivaraman and Lavanya Pelluri and Barber, {Thomas M.} and Vinod Menon and Randeva, {Harpal S.} and Miroslav Tedla and Weickert, {Martin O.}",
year = "2018",
month = "8",
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Kyrou, I, Adesanya, O, Hedley, N, Wayte, S, Grammatopoulos, D, Thomas, CL, Weedall, A, Sivaraman, S, Pelluri, L, Barber, TM, Menon, V, Randeva, HS, Tedla, M & Weickert, MO 2018, 'Improved thyroid hypoechogenicity following bariatric-induced weight loss in euthyroid adults with severe Obesity-a pilot study', Frontiers in Endocrinology, vol. 9, 488. https://doi.org/10.3389/fendo.2018.00488

Improved thyroid hypoechogenicity following bariatric-induced weight loss in euthyroid adults with severe Obesity-a pilot study. / Kyrou, Ioannis; Adesanya, Olu; Hedley, Nicholas; Wayte, Sarah; Grammatopoulos, Dimitris; Thomas, Claire L.; Weedall, Andrew; Sivaraman, Subash; Pelluri, Lavanya; Barber, Thomas M.; Menon, Vinod; Randeva, Harpal S.; Tedla, Miroslav; Weickert, Martin O.

In: Frontiers in Endocrinology, Vol. 9, 488, 24.08.2018.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Improved thyroid hypoechogenicity following bariatric-induced weight loss in euthyroid adults with severe Obesity-a pilot study

AU - Kyrou, Ioannis

AU - Adesanya, Olu

AU - Hedley, Nicholas

AU - Wayte, Sarah

AU - Grammatopoulos, Dimitris

AU - Thomas, Claire L.

AU - Weedall, Andrew

AU - Sivaraman, Subash

AU - Pelluri, Lavanya

AU - Barber, Thomas M.

AU - Menon, Vinod

AU - Randeva, Harpal S.

AU - Tedla, Miroslav

AU - Weickert, Martin O.

PY - 2018/8/24

Y1 - 2018/8/24

N2 - Background: Obesity may affect both biochemical thyroid function tests; and thyroid morphology, as assessed using ultrasound scans (US). The aim of the present pilot study was to explore whether weight loss achieved by bariatric surgery alters thyroid US morphology including gray-scale measurements; and/or function in euthyroid adults with severe obesity. Methods: Euthyroid adults (> 18 years) with body mass index (BMI) ≥40 kg/m2 and negative thyroid peroxidase antibodies were assessed at baseline (pre-surgery) and after achieving at least 5% weight loss of their baseline body weight following bariatric surgery. Anthropometric assessments, biochemical/hormonal measurements (TSH, free-T4, free-T3, reverse-T3, and leptin) and thyroid US with gray-scale histogram analysis were performed at the baseline and post-surgery follow-up. Results: Ten Caucasian, euthyroid patients (women/men: 8/2; age: 48.6 ± 3.1 years; BMI: 51.4 ± 1.8 kg/m2) successfully completed this study with significantly decreased body weight (> 5% weight loss), waist circumference and serum leptin levels post-surgery (mean post-surgery follow-up duration: 16.5 ± 2.5 months). In parallel to the observed bariatric-induced weight loss, thyroid US echogenicity increased by 25% (p = 0.03), without significant changes in thyroid volume. No significant changes in thyroid function tests were detected. No significant correlations were observed between the increase in thyroid echogenicity and the decreases in anthropometric parameters and circulating leptin. Conclusion: Our results indicate that in euthyroid adults with severe obesity, marked weight loss achieved by bariatric surgery is associated with a parallel significant increase in the thyroid US echogenicity, suggesting that morphological changes of the thyroid in obesity are reversible with weight loss.

AB - Background: Obesity may affect both biochemical thyroid function tests; and thyroid morphology, as assessed using ultrasound scans (US). The aim of the present pilot study was to explore whether weight loss achieved by bariatric surgery alters thyroid US morphology including gray-scale measurements; and/or function in euthyroid adults with severe obesity. Methods: Euthyroid adults (> 18 years) with body mass index (BMI) ≥40 kg/m2 and negative thyroid peroxidase antibodies were assessed at baseline (pre-surgery) and after achieving at least 5% weight loss of their baseline body weight following bariatric surgery. Anthropometric assessments, biochemical/hormonal measurements (TSH, free-T4, free-T3, reverse-T3, and leptin) and thyroid US with gray-scale histogram analysis were performed at the baseline and post-surgery follow-up. Results: Ten Caucasian, euthyroid patients (women/men: 8/2; age: 48.6 ± 3.1 years; BMI: 51.4 ± 1.8 kg/m2) successfully completed this study with significantly decreased body weight (> 5% weight loss), waist circumference and serum leptin levels post-surgery (mean post-surgery follow-up duration: 16.5 ± 2.5 months). In parallel to the observed bariatric-induced weight loss, thyroid US echogenicity increased by 25% (p = 0.03), without significant changes in thyroid volume. No significant changes in thyroid function tests were detected. No significant correlations were observed between the increase in thyroid echogenicity and the decreases in anthropometric parameters and circulating leptin. Conclusion: Our results indicate that in euthyroid adults with severe obesity, marked weight loss achieved by bariatric surgery is associated with a parallel significant increase in the thyroid US echogenicity, suggesting that morphological changes of the thyroid in obesity are reversible with weight loss.

KW - Bariatric surgery

KW - Gray-scale

KW - Obesity

KW - Thyroid echogenicity

KW - TSH

KW - Ultrasound

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DO - 10.3389/fendo.2018.00488

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JF - Frontiers in Endocrinology

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