Prophylactic vaccines are an effective strategy to prevent development of many infectious diseases. With new and re-emerging infections posing increasing risks to food stocks and the health of the population in general, there is a need to improve the rationale of vaccine development. One key challenge lies in development of an effective T cell-induced response to subunit vaccines at specific sites and in different populations. Objectives: In this review, we consider how a proteomic systems-based approach can be used to identify putative novel vaccine targets, may be adopted to characterise subunit vaccines and adjuvants fully. Key findings: Despite the extensive potential for proteomics to aid our understanding of subunit vaccine nature, little work has been reported on identifying MHC 1-binding peptides for subunit vaccines generating T cell responses in the literature to date. Summary: In combination with predictive and structural biology approaches to mapping antigen presentation, proteomics offers a powerful and as yet un-tapped addition to the armoury of vaccine discovery to predict T-cell subset responses and improve vaccine design strategies.
Bibliographical noteThis is the peer reviewed version of the following article: Dunston, CR, Herbert, R & Griffiths, HR 2015, 'Improving T cell-induced response to subunit vaccines: opportunities for a proteomic systems approach' Journal of pharmacy and pharmacology, vol 67, no. 3, pp. 290-299, which has been published in final form at http://dx.doi.org/10.1111/jphp.12383. This article may be used for non-commercial purposes in accordance With Wiley Terms and Conditions for self-archiving.
- biotechnology and drug discovery
- rational vaccine design