In Situ Fabrication of Silver Peroxide Hybrid Ultrathin Co-Based Metal–Organic Frameworks for Enhanced Chemodynamic Antibacterial Therapy

Mengmeng Xu, Fangrong Tan, Wanru Luo, Yifan Jia, Yan Deng, Paul D. Topham, LinGe Wang, Qianqian Yu

Research output: Contribution to journalArticlepeer-review


Bacterial-induced infectious diseases have always caused an unavoidable problem and lead to an increasing threat to human health. Hence, there is an urgent need for effective antibacterial strategies to treat infectious diseases. Current methods are often ineffective and require large amounts of hydrogen peroxide (H2O2), with harmful effects on normal healthy tissue. Chemodynamic therapy (CDT) provides an ideal infection microenvironment (IME)-activated paradigm to tackle bacterial-related diseases. To take full advantage of the specificity of IME and enhanced CDT for wounds with bacterial infection, we have designed an intelligent antibacterial system that exploits nanocatalytic ZIF-67@Ag2O2 nanosheets. In this system, silver peroxide nanoparticles (Ag2O2 NPs) were grown on ultrathin zeolitic imidazolate framework-67 (ZIF-67) nanosheets by in situ oxidation, and then, ZIF-67@Ag2O2 nanosheets with the ability to self-generate H2O2 were triggered by the mildly acidic environment of IME. Lamellar ZIF-67 nanosheets were shown to rapidly degrade and release Co2+, allowing the conversion of less reactive H2O2 into the highly toxic reactive oxygen species hydroxyl radicals (•OH) for enhanced CDT antibacterial properties. In vivo results revealed that the ZIF-67@Ag2O2 nanosheet system exhibits excellent antibacterial performance against both Gram-positive (Staphylococcus aureus) and Gram-negative (Escherichia coli) bacteria. The proposed hybrid strategy demonstrates a promising therapeutic strategy to enable antibacterial agents with IME-responsive nanocatalytic activity to circumvent antibiotic resistance against bacterial infections.
Original languageEnglish
Pages (from-to)22985-22998
Number of pages14
JournalACS Applied Materials and Interfaces
Issue number19
Early online date8 May 2023
Publication statusPublished - 17 May 2023

Bibliographical note

Copyright © 2023 American Chemical Society. This document is the Accepted Manuscript version of a Published Work that appeared in final form in ACS Applied Materials and Interfaces, copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see:

Acknowledgements: The authors thank the financial support from National Key R&D Program of China (2021YFB3802700), National Natural Science Foundation of China (No. 21807046), National Natural Science Foundation of Guangdong (No.2020A151501744), Science and Technology Program of Guangzhou (No. 202102020759), and Guangdong Basic and Applied Basic Research Foundation (No. 2021A1515111174).


  • IME-activated
  • ZIF-67 nanosheets
  • antibacterial effect
  • chemodynamic therapy
  • wound healing


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