In-vitro particle image velocimetry assessment of the endovascular haemodynamic features distal of stent-grafts that are associated with development of limb occlusion

Sina G. Yazdi*, Paul D. Docherty, Adib Khanafer, Mark Jermy, Natalia Kabaliuk, Patrick H. Geoghegan, Petra Williamson

*Corresponding author for this work

Research output: Contribution to journalArticle

Abstract

Aneurysms are common vascular diseases which affect normal haemodynamics in the aorta. Endovascular aortic repair (EVAR) using stent-grafts is a common treatment that excludes the aneurysm from the circulation, preventing further growth and eventual rupture. However, complications such as endoleak, dislocation or limb occlusion have been reported after EVAR. This study hypothesized that the compliance mismatch between the graft and parent artery causes haemodynamic disturbances at the distal edge of the graft. Therefore, the potential for the graft to cause limb occlusion was assessed. A compliant phantom was fabricated. A circulatory loop was developed to run the fluid and generate a physiological flow waveform. Particle Image Velocimetry was utilised to capture fluid dynamics in the replica. The result showed a low velocity region at the graft trailing edge wall. The low velocity boundary layer thickness decreased downstream of the graft. A flow recirculation was initiated and increased in size during the mid-acceleration at the low velocity region. Shear stresses fluctuated at the trailing edge of the graft which is a risk factor for intimal thickening followed by graft or limb occlusion. It was concluded that this haemodynamic behaviour was due to the graft and parent artery compliance mismatch.
Original languageEnglish
Number of pages14
JournalJournal of the Royal Society of New Zealand
Early online date12 Oct 2020
DOIs
Publication statusE-pub ahead of print - 12 Oct 2020

Bibliographical note

This is an Accepted Manuscript of an article published by Taylor & Francis Group in Journal of the Royal Society of New Zealand on 12 Oct 2020, available online at: http://www.tandfonline.com/10.1080/03036758.2020.1826988

Keywords

  • Multidisciplinary

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