Innovations in high throughput manufacturing of uniform emulsions and capsules

Qingchun Yuan, Richard A. Williams, Nita Aryanti

Research output: Contribution to journalReview article

Abstract

Membrane emulsification has been widely used in the manufacture of uniform soft and hard spherical particles. It is used to create uniform emulsion droplets whose sizes can be closely controlled. A disperse liquid phase is pressurised to permeate into the pores of a membrane, forming droplets in a drop-by-drop manner in a continuous phase on the other side of the membrane. The droplets formed are detached by applying well controlled detachment forces, which are result from the cross-flow of the continuous phase over the membrane surface, or the rotation of the membrane in the continuous phase. These two technologies are called cross-flow and rotating membrane emulsification, respectively. This paper presents examples of uniform complex spheres, sized from sub-micrometers to a few hundred micrometers, prepared using a pilot scale cross-flow membrane emulsification rig and a bentchtop rotating reactor. Emulsion stabilisation strategies vary from using small molecular surfactants, nanoparticles to surfactant free interfacial polymerisation. The examples demonstrate the advantages and versatility in formulation and manufacture of precisely size- and structure-controlled products using membranes.

Original languageEnglish
Pages (from-to)599-608
Number of pages10
JournalAdvanced Powder Technology
Volume21
Issue number6
DOIs
Publication statusPublished - 1 Nov 2010

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Emulsions
Capsules
Innovation
Throughput
Membranes
Emulsification
Surface-Active Agents
Surface active agents
Stabilization
Polymerization
Nanoparticles
Liquids

Keywords

  • Encapsulation
  • Membrane emulsification
  • Microcapsule
  • Uniform emulsion

Cite this

Yuan, Qingchun ; Williams, Richard A. ; Aryanti, Nita. / Innovations in high throughput manufacturing of uniform emulsions and capsules. In: Advanced Powder Technology. 2010 ; Vol. 21, No. 6. pp. 599-608.
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Innovations in high throughput manufacturing of uniform emulsions and capsules. / Yuan, Qingchun; Williams, Richard A.; Aryanti, Nita.

In: Advanced Powder Technology, Vol. 21, No. 6, 01.11.2010, p. 599-608.

Research output: Contribution to journalReview article

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AB - Membrane emulsification has been widely used in the manufacture of uniform soft and hard spherical particles. It is used to create uniform emulsion droplets whose sizes can be closely controlled. A disperse liquid phase is pressurised to permeate into the pores of a membrane, forming droplets in a drop-by-drop manner in a continuous phase on the other side of the membrane. The droplets formed are detached by applying well controlled detachment forces, which are result from the cross-flow of the continuous phase over the membrane surface, or the rotation of the membrane in the continuous phase. These two technologies are called cross-flow and rotating membrane emulsification, respectively. This paper presents examples of uniform complex spheres, sized from sub-micrometers to a few hundred micrometers, prepared using a pilot scale cross-flow membrane emulsification rig and a bentchtop rotating reactor. Emulsion stabilisation strategies vary from using small molecular surfactants, nanoparticles to surfactant free interfacial polymerisation. The examples demonstrate the advantages and versatility in formulation and manufacture of precisely size- and structure-controlled products using membranes.

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