Large-scale functional network dynamics in human callosal agenesis: Increased subcortical involvement and preserved laterality

Vanessa Siffredi; Younes Farouj; Anjali Tarun; Vicki Anderson; Amanda G. Wood; Alissandra Mcilroy; Richard J. Leventer; Megan M. Spencer-smith; Dimitri Van De Ville

doi:10.1016/j.neuroimage.2021.118471

Large-scale functional network dynamics in human callosal agenesis: Increased subcortical involvement and preserved laterality

Vanessa Siffredi^*, Younes Farouj, Anjali Tarun, Vicki Anderson, Amanda G. Wood, Alissandra Mcilroy, Richard J. Leventer, Megan M. Spencer-smith, Dimitri Van De Ville

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

Abstract

In the human brain, the corpus callosum is the major white-matter commissural tract enabling the transmission of sensory-motor, and higher level cognitive information between homotopic regions of the two cerebral hemispheres. Despite developmental absence (i.e., agenesis) of the corpus callosum (AgCC), functional connectivity is preserved, including interhemispheric connectivity. Subcortical structures have been hypothesised to provide alternative pathways to enable this preservation. To test this hypothesis, we used functional Magnetic Resonance Imaging (fMRI) recordings in children with AgCC and typically developing children, and a time-resolved approach to retrieve temporal characteristics of whole-brain functional networks. We observed an increased engagement of the cerebellum and amygdala/hippocampus networks in children with AgCC compared to typically developing children. There was little evidence that laterality of activation networks was affected in AgCC. Our findings support the hypothesis that subcortical structures play an essential role in the functional reconfiguration of the brain in the absence of a corpus callosum.

Original language	English
Article number	118471
Journal	NeuroImage
Volume	243
Early online date	27 Aug 2021
DOIs	https://doi.org/10.1016/j.neuroimage.2021.118471
Publication status	Published - 1 Nov 2021

Bibliographical note

©2021 The Authors. Published by Elsevier Inc. This is an open access article under the CC BY-NC-ND license ( http://creativecommons.org/licenses/by-nc-nd/4.0/)

Funding: This study was supported by the Boninchi Foundation from the University of Geneva; the Victorian Government’s Operational Infrastructure Support Program; and the Murdoch Children’s Research Institute. Younes Farouj and Anjali Tarun are supported by the Swiss National Science Foundation Project [205321_163376]. Professor Amanda G. Wood is supported by a European Research Council Consolidator Fellowship [682734]. Associate Professor Richard J. Leventer is supported by a Melbourne Children’s Clinician Scientist Fellowship. Professor Vicki Anderson was supported by the Australian National Health and Medical Research Council Senior Practitioner Fellowship.

Keywords

Brain plasticity
Callosal agenesis
Dynamic functional connectivity
Subcortical networks

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10.1016/j.neuroimage.2021.118471Licence: CC BY-NC-ND 3.0

Large-scale functional network dynamics in human callosal agenesis
©2021 The Authors. Published by Elsevier Inc. This is an open access article under the CC BY-NC-ND license ( http://creativecommons.org/licenses/by-nc-nd/4.0/)
Final published version, 1.16 MBLicence: CC BY-NC-ND 3.0

Cite this

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title = "Large-scale functional network dynamics in human callosal agenesis: Increased subcortical involvement and preserved laterality",

abstract = "In the human brain, the corpus callosum is the major white-matter commissural tract enabling the transmission of sensory-motor, and higher level cognitive information between homotopic regions of the two cerebral hemispheres. Despite developmental absence (i.e., agenesis) of the corpus callosum (AgCC), functional connectivity is preserved, including interhemispheric connectivity. Subcortical structures have been hypothesised to provide alternative pathways to enable this preservation. To test this hypothesis, we used functional Magnetic Resonance Imaging (fMRI) recordings in children with AgCC and typically developing children, and a time-resolved approach to retrieve temporal characteristics of whole-brain functional networks. We observed an increased engagement of the cerebellum and amygdala/hippocampus networks in children with AgCC compared to typically developing children. There was little evidence that laterality of activation networks was affected in AgCC. Our findings support the hypothesis that subcortical structures play an essential role in the functional reconfiguration of the brain in the absence of a corpus callosum.",

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author = "Vanessa Siffredi and Younes Farouj and Anjali Tarun and Vicki Anderson and Wood, {Amanda G.} and Alissandra Mcilroy and Leventer, {Richard J.} and Spencer-smith, {Megan M.} and Ville, {Dimitri Van De}",

note = "{\textcopyright}2021 The Authors. Published by Elsevier Inc. This is an open access article under the CC BY-NC-ND license ( http://creativecommons.org/licenses/by-nc-nd/4.0/) Funding: This study was supported by the Boninchi Foundation from the University of Geneva; the Victorian Government{\textquoteright}s Operational Infrastructure Support Program; and the Murdoch Children{\textquoteright}s Research Institute. Younes Farouj and Anjali Tarun are supported by the Swiss National Science Foundation Project [205321_163376]. Professor Amanda G. Wood is supported by a European Research Council Consolidator Fellowship [682734]. Associate Professor Richard J. Leventer is supported by a Melbourne Children{\textquoteright}s Clinician Scientist Fellowship. Professor Vicki Anderson was supported by the Australian National Health and Medical Research Council Senior Practitioner Fellowship. ",

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doi = "10.1016/j.neuroimage.2021.118471",

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AU - Farouj, Younes

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AU - Anderson, Vicki

AU - Wood, Amanda G.

AU - Mcilroy, Alissandra

AU - Leventer, Richard J.

AU - Spencer-smith, Megan M.

AU - Ville, Dimitri Van De

N1 - ©2021 The Authors. Published by Elsevier Inc. This is an open access article under the CC BY-NC-ND license ( http://creativecommons.org/licenses/by-nc-nd/4.0/) Funding: This study was supported by the Boninchi Foundation from the University of Geneva; the Victorian Government’s Operational Infrastructure Support Program; and the Murdoch Children’s Research Institute. Younes Farouj and Anjali Tarun are supported by the Swiss National Science Foundation Project [205321_163376]. Professor Amanda G. Wood is supported by a European Research Council Consolidator Fellowship [682734]. Associate Professor Richard J. Leventer is supported by a Melbourne Children’s Clinician Scientist Fellowship. Professor Vicki Anderson was supported by the Australian National Health and Medical Research Council Senior Practitioner Fellowship.

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N2 - In the human brain, the corpus callosum is the major white-matter commissural tract enabling the transmission of sensory-motor, and higher level cognitive information between homotopic regions of the two cerebral hemispheres. Despite developmental absence (i.e., agenesis) of the corpus callosum (AgCC), functional connectivity is preserved, including interhemispheric connectivity. Subcortical structures have been hypothesised to provide alternative pathways to enable this preservation. To test this hypothesis, we used functional Magnetic Resonance Imaging (fMRI) recordings in children with AgCC and typically developing children, and a time-resolved approach to retrieve temporal characteristics of whole-brain functional networks. We observed an increased engagement of the cerebellum and amygdala/hippocampus networks in children with AgCC compared to typically developing children. There was little evidence that laterality of activation networks was affected in AgCC. Our findings support the hypothesis that subcortical structures play an essential role in the functional reconfiguration of the brain in the absence of a corpus callosum.

AB - In the human brain, the corpus callosum is the major white-matter commissural tract enabling the transmission of sensory-motor, and higher level cognitive information between homotopic regions of the two cerebral hemispheres. Despite developmental absence (i.e., agenesis) of the corpus callosum (AgCC), functional connectivity is preserved, including interhemispheric connectivity. Subcortical structures have been hypothesised to provide alternative pathways to enable this preservation. To test this hypothesis, we used functional Magnetic Resonance Imaging (fMRI) recordings in children with AgCC and typically developing children, and a time-resolved approach to retrieve temporal characteristics of whole-brain functional networks. We observed an increased engagement of the cerebellum and amygdala/hippocampus networks in children with AgCC compared to typically developing children. There was little evidence that laterality of activation networks was affected in AgCC. Our findings support the hypothesis that subcortical structures play an essential role in the functional reconfiguration of the brain in the absence of a corpus callosum.

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JO - NeuroImage

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ER -

Large-scale functional network dynamics in human callosal agenesis: Increased subcortical involvement and preserved laterality

Abstract

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Keywords

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