Laser doppler spectrum decomposition applied in diagnostics of microcirculatory disturbances

Evgeny A. Zherebtsov, Victor V. Dremin, Elena V. Zharkikh, Andrey V. Dunaev, Igor O. Kozlov, Edik U. Rafailov, Angelina I. Zherebtsova, Jürgen Popp (Editor), Valery V. Tuchin, Francesco S. Pavone (Editor)

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Laser Doppler flowmetry (LDF) is widely used to study blood microcirculation in the skin. However, during tradition signal processing based on the integral estimations of the power spectrum of detector photocurrent, the significant part of the information about the skin blood ow is lost. In this study, we propose to analyse the distribution of the blood perfusion over the Doppler shift frequencies, which correlate with the RBC velocity. This approach provides localisation of the blood ow oscillations in different subranges of the Doppler shift. The method applied together with the wavelet analysis has been tested in healthy volunteers and patients with psoriasis on the unaffected surface of the skin. It was revealed, that the significant difference in the amplitude of myogenic oscillations is allocated in the region of the low frequency Doppler shift (1-200 Hz). This frequency region can be associated with the signal from slow components of the skin microcirculation, that can point out on a different state of the lymphatic system of the skin in psoriasis.
Original languageEnglish
Title of host publicationProceedings of SPIE
PublisherSPIE
Number of pages4
Volume10685
DOIs
Publication statusPublished - 17 May 2018
EventBiophotonics: Photonic Solutions for Better Health Care - Strasbourg, France
Duration: 22 Apr 201826 Apr 2018

Publication series

NameProceedings of SPIE
PublisherSPIE
Volume 10685
ISSN (Print)0277-786X

Conference

ConferenceBiophotonics: Photonic Solutions for Better Health Care
Period22/04/1826/04/18

Bibliographical note

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    Zherebtsov, E. A., Dremin, V. V., Zharkikh, E. V., Dunaev, A. V., Kozlov, I. O., Rafailov, E. U., Zherebtsova, A. I., Popp, J. (Ed.), Tuchin, V. V., & Pavone, F. S. (Ed.) (2018). Laser doppler spectrum decomposition applied in diagnostics of microcirculatory disturbances. In Proceedings of SPIE (Vol. 10685 ). [106854O] (Proceedings of SPIE; Vol. 10685 ). SPIE. https://doi.org/10.1117/12.2289551