TY - JOUR
T1 - Laser-induced generation of singlet oxygen and its role in the cerebrovascular physiology
AU - Semyachkina-Glushkovskaya, O.V.
AU - Sokolovski, S.G.
AU - Goltsov, A.
AU - Gekaluyk, A.S.
AU - Saranceva, E.I.
AU - Bragina, O.A.
AU - Tuchin, V.V.
AU - Rafailov, E.U.
N1 - Funding: Grant of Russian Ministy of Science and Education (12.1223.2017/AP); Europe Union's H2020, FET-open scheme through “MESO-BRAIN” project (713140); Russian Science Foundation no. 16-15-10252; Russia Foundation of Basic Research (17-02-00358-a); and the Russian Presidential grant (NSh-7898.2016.2).
PY - 2017/5/25
Y1 - 2017/5/25
N2 - For over 55 years, laser technology has expanded from laboratory research to widespread fields, for example telecommunication and data storage amongst others. Recently application of lasers in biology and medicine presents itself as one of the emerging areas. In this review, we will outline the recent advances in using lasers for the generation of singlet oxygen, traditionally used to kill tumour cells or induce thrombotic stroke model due to damage vascular effects. Over the last two decade, completely new results on cerebrovascular effects of singlet oxygen generated during photodynamic therapy (PDT) have been shown alongside promising applications for delivery of drugs and nanoparticles into the brain for therapy of brain cancer. Furthermore, a "gold key" has been found to overcome the limitations of PDT, such as low light penetration and high toxicity of photosensitizers, by direct generation of singlet oxygen using quantum-dot laser diodes emitting in the near infrared (NIR) spectral range. It is our motivation to highlight these pioneering results in this review, to improve understanding of the biological role of singlet oxygen and to provide new perspectives for improving clinical application of laser based therapy in further research.
AB - For over 55 years, laser technology has expanded from laboratory research to widespread fields, for example telecommunication and data storage amongst others. Recently application of lasers in biology and medicine presents itself as one of the emerging areas. In this review, we will outline the recent advances in using lasers for the generation of singlet oxygen, traditionally used to kill tumour cells or induce thrombotic stroke model due to damage vascular effects. Over the last two decade, completely new results on cerebrovascular effects of singlet oxygen generated during photodynamic therapy (PDT) have been shown alongside promising applications for delivery of drugs and nanoparticles into the brain for therapy of brain cancer. Furthermore, a "gold key" has been found to overcome the limitations of PDT, such as low light penetration and high toxicity of photosensitizers, by direct generation of singlet oxygen using quantum-dot laser diodes emitting in the near infrared (NIR) spectral range. It is our motivation to highlight these pioneering results in this review, to improve understanding of the biological role of singlet oxygen and to provide new perspectives for improving clinical application of laser based therapy in further research.
UR - http://www.scopus.com/inward/record.url?scp=85025169720&partnerID=8YFLogxK
UR - https://www.sciencedirect.com/science/article/pii/S0079672717300149
U2 - 10.1016/j.pquantelec.2017.05.001
DO - 10.1016/j.pquantelec.2017.05.001
M3 - Article
AN - SCOPUS:85025169720
SN - 0079-6727
VL - 55
SP - 112
EP - 128
JO - Progress in Quantum Electronics
JF - Progress in Quantum Electronics
ER -